Microvascular changes in eyes with non-proliferative diabetic retinopathy with or without macular microaneurysms: an OCT-angiography study.

IF 3.1 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Acta Diabetologica Pub Date : 2024-10-24 DOI:10.1007/s00592-024-02394-y
Caterina Toma, Elena Cavallari, Paola Varano, Andrea Servillo, Valentina Gatti, Daniela Ferrante, Emanuele Torti, Andrea Muraca, Stefano De Cillà
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Abstract

Purpose: To evaluate different quantitative non-invasive retinal biomarkers of microvascular impairment and neurodegeneration in patients affected by mild and moderate non proliferative diabetic retinopathy (NPDR) with or without macular microaneurysms (MAs).

Methods: A cross-sectional case-control study. Ninety-seven eyes with NPDR, 49 with no central MAs and 48 with central MAs, underwent color fundus photography and optical coherence tomography (OCT)/OCT-angiography (OCT-A). Thickness of central macula, retinal nerve fiber layer (NFL), ganglion cell layer (GCL+) and NFL + GCL + was evaluated on OCT. FAZ metrics (ImageJ), perfusion and vessel density (PD/VD), and fractal dimension (FD) (MATLAB) were evaluated on 3 × 3 OCT-A slabs of both superficial and deep capillary plexuses (SCP/DCP). All evaluations were performed on the full image and after subdivision in 4 quadrants.

Results: In the MA group, 77 MAs were detected (45.5% in the DCP). The MA group showed: increased FAZ area and perimeter in the SCP (p < 0.01) and DCP (p = 0.02), and reduced circularity index in the SCP (p = 0.03); reduced VD in the SCP (p < 0.01) and reduced PD, VD (p < 0.01) and FD (p = 0.02) in the DCP; decreased VD and FD in the SCP (p = 0.02 and p = 0.05), and in VD and FD in the DCP in the inferior quadrant (p = 0.04 and p = 0.03); a decrease in VD in the SCP in the nasal quadrant (p = 0.05). No differences have been detected in OCT parameters.

Conclusions: Our results suggest that the presence of central MAs in patients with NPDR may correlate with more pronounced macular microvascular impairment, particularly during the mild and moderate stages of the disease.

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伴有或不伴有黄斑微动脉瘤的非增生性糖尿病视网膜病变眼球中的微血管变化:OCT 血管造影研究。
目的:评估轻度和中度非增殖性糖尿病视网膜病变(NPDR)患者伴有或不伴有黄斑微动脉瘤(MAs)的微血管损伤和神经变性的不同定量非侵入性视网膜生物标记物:方法:横断面病例对照研究。97只患有NPDR的眼睛接受了彩色眼底照相和光学相干断层扫描(OCT)/OCT-血管成像(OCT-A)检查,其中49只眼睛没有中心黄斑微动脉瘤,48只眼睛有中心黄斑微动脉瘤。OCT 评估了中心黄斑、视网膜神经纤维层(NFL)、神经节细胞层(GCL+)和 NFL + GCL + 的厚度。在浅层和深层毛细血管丛(SCP/DCP)的 3 × 3 OCT-A 片上评估了 FAZ 指标(ImageJ)、灌注和血管密度(PD/VD)以及分形维度(FD)(MATLAB)。所有评估均在完整图像上进行,并在 4 个象限细分后进行:在 MA 组中,检测到 77 个 MA(在 DCP 中占 45.5%)。MA组显示:SCP中的FAZ面积和周长增加(p 结论:MA组显示:SCP中的FAZ面积和周长增加(p):我们的研究结果表明,NPDR 患者中央 MA 的存在可能与更明显的黄斑微血管损伤有关,尤其是在疾病的轻度和中度阶段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Diabetologica
Acta Diabetologica 医学-内分泌学与代谢
CiteScore
7.30
自引率
2.60%
发文量
180
审稿时长
2 months
期刊介绍: Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.
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