Microvascular and Structural Characterization of Birdshot Chorioretinitis in Active and Inactive Phases.

IF 3.9 3区 工程技术 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomedicines Pub Date : 2024-10-21 DOI:10.3390/biomedicines12102414
Aina Moll-Udina, Marina Dotti-Boada, Anabel Rodríguez, Maite Sainz-de-la-Maza, Alfredo Adán, Victor Llorenç
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Abstract

Objective: This study aimed to examine microvascular changes and identify predictors of short-term quiescence in active birdshot chorioretinitis (BSCR). Methods: An observational, prospective, 12-month follow-up cohort study was conducted. BSCR eyes were clinically assessed at baseline, categorized as active or inactive, and reevaluated at 12 months. Based on their clinical activity at both timepoints, eyes were divided into three subgroups: active-to-inactive (A-I), consistently active (A-A), and consistently inactive (I-I). Structural OCT, OCT-angiography (OCT-A), and ultra-widefield imaging were utilized. Exam data from fundus and nasal subfields were analyzed for microvascular changes and quiescence predictors. Results: Sixty eyes from 30 BSCR patients (47% women, 53% men, mean age 59.7 ± 12.3 years) were included. In the A-I group (16 eyes), vascular density and perfusion indices increased in all subfields post-quiescence, contrasting with the other groups. Perifoveal looping in the superficial capillary plexus predicted quiescence at 12 months compared with the A-A group. Conclusions: Vascular density rises after complete inflammation control in BSCR, and perifoveal capillary loops serve as potential predictors of short-term quiescence in active BSCR.

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活动期和非活动期鸟枪状脉络膜视网膜炎的微血管和结构特征。
研究目的本研究旨在检查活动性鸟枪状脉络膜视网膜炎(BSCR)的微血管变化并确定短期静止的预测因素。研究方法进行了一项为期 12 个月的前瞻性队列观察研究。在基线时对 BSCR 眼球进行临床评估,将其分为活动性和非活动性,并在 12 个月时进行再次评估。根据两个时间点的临床活动情况,眼球被分为三个亚组:活动至不活动(A-I)、持续活动(A-A)和持续不活动(I-I)。采用结构性 OCT、OCT 血管造影(OCT-A)和超宽场成像。对眼底和鼻腔子场的检查数据进行分析,以了解微血管变化和静止预测因素。结果共纳入 30 名 BSCR 患者的 60 只眼睛(女性占 47%,男性占 53%,平均年龄为 59.7 ± 12.3 岁)。在 A-I 组(16 只眼)中,所有亚领域的血管密度和灌注指数在静止后都有所增加,与其他组形成鲜明对比。与 A-A 组相比,浅层毛细血管丛的眼周环路预示着 12 个月后的静止。结论BSCR的血管密度在炎症完全控制后会上升,眼周毛细血管襻是活动性BSCR短期静止的潜在预测因子。
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来源期刊
Biomedicines
Biomedicines Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.20
自引率
8.50%
发文量
2823
审稿时长
8 weeks
期刊介绍: Biomedicines (ISSN 2227-9059; CODEN: BIOMID) is an international, scientific, open access journal on biomedicines published quarterly online by MDPI.
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