Jose Antonio Almario, Amit Mehta, Apurva Shrigiriwar, Farimah Fayyaz, Mohamed El-Sherbiny, Karim Essam, Hany Haggag, Kerolis Yousef, Abeer A Abdallatef, Shaimaa Elkholy, Andrew Canakis, Raymond E Kim, Dennis Yang, Miguel Puga-Tejada, Juan Alcívar-Vásquez, Maria Egas-Izquierdo, Raquel S Del Valle, Domenica Cunto, Jorge Baquerizo-Burgos, Martha Arevalo-Mora, Carlos Robles-Medranda, Aleksandra Borkowicz, Michał F Kamiński, Michael Lajin, Prashant Kedia, Mouen A Khashab
{"title":"Short-term clinical and technical outcomes of a modified Zenker's peroral endoscopic myotomy with mucosal flap incision.","authors":"Jose Antonio Almario, Amit Mehta, Apurva Shrigiriwar, Farimah Fayyaz, Mohamed El-Sherbiny, Karim Essam, Hany Haggag, Kerolis Yousef, Abeer A Abdallatef, Shaimaa Elkholy, Andrew Canakis, Raymond E Kim, Dennis Yang, Miguel Puga-Tejada, Juan Alcívar-Vásquez, Maria Egas-Izquierdo, Raquel S Del Valle, Domenica Cunto, Jorge Baquerizo-Burgos, Martha Arevalo-Mora, Carlos Robles-Medranda, Aleksandra Borkowicz, Michał F Kamiński, Michael Lajin, Prashant Kedia, Mouen A Khashab","doi":"10.1055/a-2451-2869","DOIUrl":null,"url":null,"abstract":"<p><p>Zenker's diverticulum peroral endoscopic myotomy (Z-POEM) is an effective treatment for symptomatic Zenker's diverticulum. A modification to Z-POEM involves mucosal flap incision (MFI). We describe the technical and clinical success of patients who underwent Z-POEM with MFI.We included patients who underwent Z-POEM with MFI for Zenker's diverticulum at eight international centers. The primary outcome was the rate of clinical success, assessed by post-procedure Kothari-Haber symptom score (KHSS) without re-treatment. Secondary outcomes included technical success, serious adverse events, and clinical recurrence with need for re-treatment.36 patients (age 69 [SD 9] years; 69% male) underwent Z-POEM with MFI for symptomatic Zenker's diverticulum. Mean diverticulum size was 3.2 (SD 1.4) cm. Clinical success was achieved in 35 patients (97%). Median baseline KHSS was 6 and median post-procedure KHSS was 0 (P < 0.001). Technical success was achieved in all cases. Mean procedure time was 57 (SD 34) minutes and median follow-up time was 196 days (interquartile range 39-499). There was one adverse event (3%), which was treated endoscopically.Z-POEM with MFI had high rates of technical and clinical success. Prospective evaluation is needed to further validate this technique in patients with a large Zenker's diverticulum.</p>","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.5000,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endoscopy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/a-2451-2869","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Zenker's diverticulum peroral endoscopic myotomy (Z-POEM) is an effective treatment for symptomatic Zenker's diverticulum. A modification to Z-POEM involves mucosal flap incision (MFI). We describe the technical and clinical success of patients who underwent Z-POEM with MFI.We included patients who underwent Z-POEM with MFI for Zenker's diverticulum at eight international centers. The primary outcome was the rate of clinical success, assessed by post-procedure Kothari-Haber symptom score (KHSS) without re-treatment. Secondary outcomes included technical success, serious adverse events, and clinical recurrence with need for re-treatment.36 patients (age 69 [SD 9] years; 69% male) underwent Z-POEM with MFI for symptomatic Zenker's diverticulum. Mean diverticulum size was 3.2 (SD 1.4) cm. Clinical success was achieved in 35 patients (97%). Median baseline KHSS was 6 and median post-procedure KHSS was 0 (P < 0.001). Technical success was achieved in all cases. Mean procedure time was 57 (SD 34) minutes and median follow-up time was 196 days (interquartile range 39-499). There was one adverse event (3%), which was treated endoscopically.Z-POEM with MFI had high rates of technical and clinical success. Prospective evaluation is needed to further validate this technique in patients with a large Zenker's diverticulum.
期刊介绍:
Endoscopy is a leading journal covering the latest technologies and global advancements in gastrointestinal endoscopy. With guidance from an international editorial board, it delivers high-quality content catering to the needs of endoscopists, surgeons, clinicians, and researchers worldwide. Publishing 12 issues each year, Endoscopy offers top-quality review articles, original contributions, prospective studies, surveys of diagnostic and therapeutic advances, and comprehensive coverage of key national and international meetings. Additionally, articles often include supplementary online video content.