Hydroxypropyl Cellulose Hydrogel Containing Origanum vulgare ssp. hirtum Essential-Oil-Loaded Polymeric Micelles for Enhanced Treatment of Melanoma.

IF 5 3区化学 Q1 POLYMER SCIENCE Gels Pub Date : 2024-09-29 DOI:10.3390/gels10100627

Katya Kamenova, Ivan Iliev, Anna Prancheva, Pencho Tuleshkov, Krasimir Rusanov, Ivan Atanassov, Petar D Petrov

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Abstract

Origanum vulgare ssp. hirtum essential oil (OEO) is a natural oil with high therapeutic potential. For some applications, however, the development of novel formulations is still needed to improve the bioavailability and stability of OEO. In this study, we describe the fabrication of an original nanocomposite hydroxypropyl cellulose (HPC) physical hydrogel, containing OEO-loaded polymeric micelles, for topical delivery. The concentration of the main active compounds of OEO-carvacol and thymol-was determined using gas chromatography (GC) analysis. OEO was first encapsulated into Pluronic F127 micelles, and then embedded into HPC gel. Micellar and gel formulations of pure polymers and OEO-containing systems were characterized by dynamic light scattering (DLS) and rheology measurements, respectively. Selected formulations were evaluated for cytotoxicity and antiproliferative activity. The hydrogel formulation of HPC with micellar OEO (8% HPC, 2% F127, 1% OEO) exhibited sustained release of the oil and selectivity towards SH-4 tumor cells (an in vitro model of melanoma).

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含有牛至精油的羟丙基纤维素水凝胶用于增强黑色素瘤的治疗效果

牛至精油（OEO）是一种具有极高治疗潜力的天然精油。然而，在某些应用中，仍需要开发新型配方来提高 OEO 的生物利用度和稳定性。在本研究中，我们介绍了一种独创的纳米复合羟丙基纤维素（HPC）物理水凝胶的制备方法，其中含有负载 OEO 的聚合物胶束，可用于局部给药。OEO 的主要活性化合物香芹酚和百里酚的浓度是通过气相色谱（GC）分析测定的。首先将 OEO 包入 Pluronic F127 胶束，然后嵌入 HPC 凝胶。纯聚合物和含 OEO 系统的胶束和凝胶配方分别通过动态光散射（DLS）和流变学测量进行了表征。对所选配方进行了细胞毒性和抗增殖活性评估。含胶束 OEO 的 HPC 水凝胶配方（8% HPC、2% F127、1% OEO）表现出油的持续释放性和对 SH-4 肿瘤细胞（黑色素瘤的体外模型）的选择性。

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来源期刊

Gels POLYMER SCIENCE-

CiteScore

4.70

自引率

19.60%

发文量

707

审稿时长

11 weeks

期刊介绍： The journal Gels (ISSN 2310-2861) is an international, open access journal on physical (supramolecular) and chemical gel-based materials. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the maximum length of the papers, and full experimental details must be provided so that the results can be reproduced. Short communications, full research papers and review papers are accepted formats for the preparation of the manuscripts. Gels aims to serve as a reference journal with a focus on gel materials for researchers working in both academia and industry. Therefore, papers demonstrating practical applications of these materials are particularly welcome. Occasionally, invited contributions (i.e., original research and review articles) on emerging issues and high-tech applications of gels are published as special issues.