Functional Scaffolds for Bone Tissue Regeneration: A Comprehensive Review of Materials, Methods, and Future Directions.

IF 5 3区医学 Q1 ENGINEERING, BIOMEDICAL Journal of Functional Biomaterials Pub Date : 2024-09-25 DOI:10.3390/jfb15100280

Emily Ann Todd, Nicholas A Mirsky, Bruno Luís Graciliano Silva, Ankita Raja Shinde, Aris R L Arakelians, Vasudev Vivekanand Nayak, Rosemary Adriana Chiérici Marcantonio, Nikhil Gupta, Lukasz Witek, Paulo G Coelho

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Abstract

Bone tissue regeneration is a rapidly evolving field aimed at the development of biocompatible materials and devices, such as scaffolds, to treat diseased and damaged osseous tissue. Functional scaffolds maintain structural integrity and provide mechanical support at the defect site during the healing process, while simultaneously enabling or improving regeneration through amplified cellular cues between the scaffold and native tissues. Ample research on functionalization has been conducted to improve scaffold-host tissue interaction, including fabrication techniques, biomaterial selection, scaffold surface modifications, integration of bioactive molecular additives, and post-processing modifications. Each of these methods plays a crucial role in enabling scaffolds to not only support but actively participate in the healing and regeneration process in bone and joint surgery. This review provides a state-of-the-art, comprehensive overview of the functionalization of scaffold-based strategies used in tissue engineering, specifically for bone regeneration. Critical issues and obstacles are highlighted, applications and advances are described, and future directions are identified.

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用于骨组织再生的功能性支架：材料、方法和未来方向综合评述》。

骨组织再生是一个快速发展的领域，旨在开发生物相容性材料和装置（如支架），以治疗病变和受损的骨组织。功能性支架可在愈合过程中保持结构的完整性，并在缺损部位提供机械支撑，同时通过放大支架与原生组织之间的细胞线索，促进或改善再生。为了改善支架与宿主组织之间的相互作用，人们对功能化进行了大量研究，包括制造技术、生物材料选择、支架表面改性、生物活性分子添加剂的整合以及后处理改性。这些方法中的每一种都在使支架不仅支持而且积极参与骨关节手术的愈合和再生过程中发挥着至关重要的作用。本综述全面概述了组织工程中使用的基于支架的功能化策略，特别是用于骨再生的策略。文章强调了关键问题和障碍，介绍了应用和进展，并指出了未来的发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Functional Biomaterials Engineering-Biomedical Engineering

CiteScore

4.60

自引率

4.20%

发文量

226

审稿时长

11 weeks

期刊介绍： Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.