Theoretical Model for In Vivo Induction of Chemotherapy Sensitization Using miRNA Packaged in Distinct Layered Liposomes.

IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Journal of Functional Biomaterials Pub Date : 2024-10-05 DOI:10.3390/jfb15100298
Ruxandra-Ioana Cipu, Mihai-Laurențiu Stănişteanu, Mihaela-Aurelia Andrei, Daniel Dumitru Banciu, Adela Banciu
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Abstract

Resistance to chemotherapy is a problem of major social and economic importance, when looking at factors like the decrease in life expectancy, the associated therapeutic costs, and a significant number of cancers that resist current chemotherapy. The development of chemotherapeutics for all theoretically possible tumor variants is an approach that requires unreasonable resources. We propose a theoretical model that serves the purpose of overcoming resistance to chemotherapeutic agents used in cancer therapy. The model describes a gene delivery system based on liposomes, which are optically guided to the tumor's location. The main aim of the gene delivery system is inhibiting the activity of enzymes involved in drug metabolism, hence offering the opportunity to use inexpensive chemotherapeutics that are already on the market. This model will reduce the costs of chemotherapy and will assure a positive outcome for patients.

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利用包装在不同层状脂质体中的 miRNA 诱导体内化疗增敏的理论模型
化疗抗药性是一个具有重大社会和经济意义的问题,其影响因素包括预期寿命的缩短、相关的治疗费用以及大量癌症对当前化疗的抗药性。针对所有理论上可能出现的肿瘤变异开发化疗药物是一种需要不合理资源的方法。我们提出了一个理论模型,用于克服癌症治疗中使用的化疗药物的抗药性。该模型描述了一种基于脂质体的基因递送系统,脂质体通过光学引导到达肿瘤位置。基因递送系统的主要目的是抑制参与药物代谢的酶的活性,从而提供了使用市场上已有的廉价化疗药物的机会。这种模式将降低化疗成本,并确保患者获得积极的治疗效果。
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来源期刊
Journal of Functional Biomaterials
Journal of Functional Biomaterials Engineering-Biomedical Engineering
CiteScore
4.60
自引率
4.20%
发文量
226
审稿时长
11 weeks
期刊介绍: Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.
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