Great Expectations: Semaglutide as Antidiabetic Weight Management in a Psychiatric Hospital.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-10-22 DOI:10.1177/08971900241294122

Krysta Shannon, Grace Shyh

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Abstract

This report explores the potential role of glucagon-like peptide 1 (GLP-1) receptor agonists in minimizing the metabolic side effects of psychotropic medications in patients with underlying type 2 diabetes (T2D) in inpatient psychiatric settings. The introduction of novel antidiabetic medications such as GLP-1 receptor agonists has broadened the options for managing metabolic disorders, particularly T2D. These medications not only offer effective glycemic control but also provide cardiovascular and renal benefits and help with weight management. Given the tendency of psychotropic medications to cause weight gain and metabolic complications, this report presents 2 cases where weekly doses of semaglutide improved blood glucose levels and prevented weight gain in patients receiving chronic psychotropic medications. Integrating GLP-1 receptor agonists into inpatient psychiatric care can help mitigate the metabolic adverse effects of psychotropic medications. However, considerations such as cost, accessibility, and institutional formulary restrictions are essential to ensure comprehensive patient care.

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美好的期望：塞马鲁肽作为精神病院的抗糖尿病体重管理药物

本报告探讨了胰高血糖素样肽 1（GLP-1）受体激动剂在尽量减少精神科住院病人潜在 2 型糖尿病（T2D）患者服用精神药物产生的代谢副作用方面的潜在作用。GLP-1 受体激动剂等新型抗糖尿病药物的问世拓宽了治疗代谢紊乱，尤其是 2 型糖尿病的选择范围。这些药物不仅能有效控制血糖，还对心血管和肾脏有益，并有助于控制体重。鉴于精神药物容易导致体重增加和代谢并发症，本报告介绍了 2 例长期服用精神药物的患者每周服用塞马鲁肽可改善血糖水平并防止体重增加的病例。将 GLP-1 受体激动剂纳入住院精神病治疗有助于减轻精神药物对代谢的不良影响。然而，成本、可及性和机构处方限制等考虑因素对于确保全面的患者护理至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.