Low Serum Fibroblast Growth Factor 21 Level and Its Altered Regulation by Thyroid Hormones in Patients with Hashimoto's Thyroiditis on Levothyroxine Substitution.

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Metabolites Pub Date : 2024-10-21 DOI:10.3390/metabo14100565
Eszter Berta, Sándor Halmi, István Molnár, Dávid Hutkai, Sára Csiha, Harjit Pal Bhattoa, Hajnalka Lőrincz, Sándor Somodi, Mónika Katkó, Mariann Harangi, György Paragh, Endre V Nagy, Miklós Bodor
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Abstract

Background/objectives: Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism exerting protection against atherosclerosis by multiple actions on the blood vessels, liver, and adipose tissues. We aimed to investigate serum FGF21 level and its relation to thyroid hormones and metabolic parameters among patients with Hashimoto's thyroiditis (HT).

Methods: Eighty patients with HT on levothyroxine treatment and eighty-two age- and BMI-matched adults without thyroid disease serving as controls were enrolled. Serum FGF21 concentrations were determined with an enzyme-linked immunosorbent assay.

Results: Median serum FGF21 level was significantly lower in HT patients compared with controls (74.2 (33.4-148.3) pg/mL vs. 131.9 (44.8-236.3) pg/mL; p = 0.03). We found a positive correlation between FGF21 and age, triglyceride, total cholesterol, and low-density lipoprotein cholesterol in both groups, while thyroid stimulating hormone and C-reactive protein showed a positive correlation, and thyroxine had an inverse correlation with FGF21 only in control subjects. According to multiple regression analyses, thyroid status is the main predictor of FGF21 in healthy controls, while it is not a significant predictor of FGF21 among HT patients on levothyroxine supplementation therapy.

Conclusions: Our results indicate that the physiological role of thyroid function in the regulation of FGF21 synthesis is impaired in HT patients, which may contribute to the metabolic alterations characteristic of HT patients.

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使用左甲状腺素替代品的桥本氏甲状腺炎患者血清成纤维细胞生长因子21水平偏低及其受甲状腺激素调节的改变
背景/目的:成纤维细胞生长因子21(FGF21)是一种脂质和葡萄糖代谢的激素调节因子,通过对血管、肝脏和脂肪组织的多重作用来防止动脉粥样硬化。我们旨在研究桥本氏甲状腺炎(HT)患者的血清 FGF21 水平及其与甲状腺激素和代谢指标的关系:招募了80名接受左甲状腺素治疗的桥本氏甲状腺炎患者和82名年龄与体重指数相匹配的无甲状腺疾病成人作为对照组。用酶联免疫吸附试验测定血清中的 FGF21 浓度:结果:与对照组相比,高密度脂蛋白血症患者血清中位 FGF21 水平明显较低(74.2 (33.4-148.3) pg/mL vs. 131.9 (44.8-236.3) pg/mL;p = 0.03)。我们发现,在两组受试者中,FGF21 与年龄、甘油三酯、总胆固醇和低密度脂蛋白胆固醇呈正相关,而促甲状腺激素和 C 反应蛋白呈正相关,只有对照组受试者的甲状腺素与 FGF21 呈反相关。根据多元回归分析,在健康对照组中,甲状腺状态是预测FGF21的主要因素,而在接受左甲状腺素补充治疗的高血压患者中,甲状腺状态并不是预测FGF21的重要因素:我们的研究结果表明,甲状腺功能在 HT 患者中调节 FGF21 合成的生理作用受损,这可能是导致 HT 患者代谢改变的原因之一。
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来源期刊
Metabolites
Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
5.70
自引率
7.30%
发文量
1070
审稿时长
17.17 days
期刊介绍: Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.
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