{"title":"Erinacenones A-L: Twelve New Isoindolinone Alkaloids from the Edible and Medicinal Mushroom <i>Hericium erinaceus</i>.","authors":"Lin-Lin Yuan, Ji-Kai Liu","doi":"10.3390/molecules29204901","DOIUrl":null,"url":null,"abstract":"<p><p>A total of twelve previously unreported isoindolin-1-one compounds, erinacenones A-L (<b>1</b>-<b>12</b>), were isolated from liquid cultures of the medicinal fungus <i>Hericium erinaceus</i>. Their structures were elucidated based on spectroscopic data analysis. The absolute configuration of <b>12</b> was determined by comparing its optical rotations with values reported in the literature. The most distinctive feature of these compounds is that their nitrogen atoms are connected to different parts of the special structure moieties. Among them, compounds <b>3</b> and <b>4</b>, as well as <b>10</b> and <b>11</b>, are two pairs of isomers differing only by a small change in the position of one double bond. Compounds <b>4</b> and <b>5</b> were found to show cytotoxic activities, with IC<sub>50</sub> values of 24.7 and 18.4 μM, respectively, against MCF-7 cell lines.</p>","PeriodicalId":19041,"journal":{"name":"Molecules","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510660/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecules","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3390/molecules29204901","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A total of twelve previously unreported isoindolin-1-one compounds, erinacenones A-L (1-12), were isolated from liquid cultures of the medicinal fungus Hericium erinaceus. Their structures were elucidated based on spectroscopic data analysis. The absolute configuration of 12 was determined by comparing its optical rotations with values reported in the literature. The most distinctive feature of these compounds is that their nitrogen atoms are connected to different parts of the special structure moieties. Among them, compounds 3 and 4, as well as 10 and 11, are two pairs of isomers differing only by a small change in the position of one double bond. Compounds 4 and 5 were found to show cytotoxic activities, with IC50 values of 24.7 and 18.4 μM, respectively, against MCF-7 cell lines.
期刊介绍：
Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.
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