Lei Li (李磊), Zhengping Ge (葛正平), Shihao Liu (刘世豪), Kun Zheng (郑坤), Yaqi Li (李亚琪), Kaiqi Chen (陈恺骐), Yesheng Fu (付业胜), Xiaoguang Lei (雷晓光), Zeling Cui (崔泽玲), Yifan Wang (王一帆), Jin Huang (黄金), Yanyan Liu (刘艳艳), Mingwang Duan (段明王), Zimei Sun (孙仔妹), Jun Chen (陈俊), Liangwei Li (李良伟), Pan Shen (沈磐), Guibin Wang (王贵宾), Junmiao Chen (陈俊苗), Ruochong Li (李若翀), Chaoran Li (李超然), Zhixiang Yang (杨志向), Yifan Ning (宁一凡), Arong Luo (罗阿蓉), Baoyu Chen (陈宝玉), Inge Seim, Xin Liu (刘心), Fei Wang (王斐), Yishan Yao (姚宜山), Fusheng Guo (郭富生), Maojun Yang (杨茂君), Cui Hua Liu (刘翠华), Guangyi Fan (范广益), Lizhi Wang (王立志), Dong Yang (杨冬), Lingqiang Zhang (张令强)
{"title":"Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade","authors":"Lei Li (李磊), Zhengping Ge (葛正平), Shihao Liu (刘世豪), Kun Zheng (郑坤), Yaqi Li (李亚琪), Kaiqi Chen (陈恺骐), Yesheng Fu (付业胜), Xiaoguang Lei (雷晓光), Zeling Cui (崔泽玲), Yifan Wang (王一帆), Jin Huang (黄金), Yanyan Liu (刘艳艳), Mingwang Duan (段明王), Zimei Sun (孙仔妹), Jun Chen (陈俊), Liangwei Li (李良伟), Pan Shen (沈磐), Guibin Wang (王贵宾), Junmiao Chen (陈俊苗), Ruochong Li (李若翀), Chaoran Li (李超然), Zhixiang Yang (杨志向), Yifan Ning (宁一凡), Arong Luo (罗阿蓉), Baoyu Chen (陈宝玉), Inge Seim, Xin Liu (刘心), Fei Wang (王斐), Yishan Yao (姚宜山), Fusheng Guo (郭富生), Maojun Yang (杨茂君), Cui Hua Liu (刘翠华), Guangyi Fan (范广益), Lizhi Wang (王立志), Dong Yang (杨冬), Lingqiang Zhang (张令强)","doi":"10.1126/science.adl0799","DOIUrl":null,"url":null,"abstract":"<div >Tardigrades are captivating organisms known for their resilience in extreme environments, including ultra-high-dose radiation, but the underlying mechanisms of this resilience remain largely unknown. Using genome, transcriptome, and proteome analysis of <i>Hypsibius henanensis</i> <b>sp. nov.</b>, we explored the molecular basis contributing to radiotolerance in this organism. A putatively horizontally transferred gene, DOPA dioxygenase 1 (<i>DODA1</i>), responds to radiation and confers radiotolerance by synthesizing betalains—a type of plant pigment with free radical–scavenging properties. A tardigrade-specific radiation-induced disordered protein, TRID1, facilitates DNA damage repair through a mechanism involving phase separation. Two mitochondrial respiratory chain complex assembly proteins, BCS1 and NDUFB8, accumulate to accelerate nicotinamide adenine dinucleotide (NAD<sup>+</sup>) regeneration for poly(adenosine diphosphate–ribosyl)ation (PARylation) and subsequent poly(adenosine diphosphate–ribose) polymerase 1 (PARP1)–mediated DNA damage repair. These three observations expand our understanding of mechanisms of tardigrade radiotolerance.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":null,"pages":null},"PeriodicalIF":44.7000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science","FirstCategoryId":"103","ListUrlMain":"https://www.science.org/doi/10.1126/science.adl0799","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Tardigrades are captivating organisms known for their resilience in extreme environments, including ultra-high-dose radiation, but the underlying mechanisms of this resilience remain largely unknown. Using genome, transcriptome, and proteome analysis of Hypsibius henanensissp. nov., we explored the molecular basis contributing to radiotolerance in this organism. A putatively horizontally transferred gene, DOPA dioxygenase 1 (DODA1), responds to radiation and confers radiotolerance by synthesizing betalains—a type of plant pigment with free radical–scavenging properties. A tardigrade-specific radiation-induced disordered protein, TRID1, facilitates DNA damage repair through a mechanism involving phase separation. Two mitochondrial respiratory chain complex assembly proteins, BCS1 and NDUFB8, accumulate to accelerate nicotinamide adenine dinucleotide (NAD+) regeneration for poly(adenosine diphosphate–ribosyl)ation (PARylation) and subsequent poly(adenosine diphosphate–ribose) polymerase 1 (PARP1)–mediated DNA damage repair. These three observations expand our understanding of mechanisms of tardigrade radiotolerance.
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