Incidence and risk factors of venous thromboembolism in patients with amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Q3 Medicine Tunisie Medicale Pub Date : 2024-10-05 DOI:10.62438/tunismed.v102i10.5154
Abdullah Ashraf Hamad, Ibraheem M Alkhawaldeh, Abdallah Abbas, Ahmed Elaraby, Mostafa Meshref
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Abstract

Aims: This systematic review and meta-analysis aimed to determine the annual incidence rate of venous thromboembolism (VTE) and identify risk factors of VTE in amyotrophic lateral sclerosis (ALS) patients.

Methods: A comprehensive search of three databases was conducted up to April 8, 2024, to identify longitudinal studies reporting VTE incidence in ALS patients. The included studies were either prospective or retrospective, following up with ALS patients. Quality assessment was performed using the NIH tool for observational cohort studies. Meta-analysis was conducted using Open Meta Analyst, employing a random-effect model. Subgroup, Meta-regression, and sensitivity analyses were also carried out.

Results: Our analysis included eight studies comprising a total of 26,758 ALS patients that met the inclusion criteria. The pooled annual incidence of VTE across all studies was found to be 22 cases per 1,000 person-year (95% CI = 18 to 27). Subgroup analysis revealed that the annual incidence of VTE in males was 19 cases per 1,000 person-year (95% CI = 15 to 22), while in females, it was 20 cases per 1,000 person-year (95% CI = 16 to 25). Leave-one-out analysis demonstrated that the incidence ranged from 21 to 28 cases per 1,000 person-year when excluding each study individually. Meta-regression analysis did not find a significant association between age and the risk of VTE (P = 0.079). Based on the included studies, risk factors of VTE in ALS patients included a history of VTE, non-invasive ventilation, immobility, and decreased functional status.

Conclusion: Patients with ALS face a higher risk of developing VTE compared to individuals of the same age. These findings underscore the importance of implementing preventive measures and closely monitoring VTE in ALS patients.

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肌萎缩侧索硬化症患者静脉血栓栓塞症的发病率和风险因素:系统回顾和荟萃分析。
目的:本系统综述和荟萃分析旨在确定肌萎缩侧索硬化症(ALS)患者静脉血栓栓塞症(VTE)的年发病率,并识别VTE的风险因素:对截至 2024 年 4 月 8 日的三个数据库进行了全面检索,以确定报告 ALS 患者 VTE 发生率的纵向研究。纳入的研究均为前瞻性或回顾性研究,对 ALS 患者进行随访。采用 NIH 观察性队列研究工具进行质量评估。采用随机效应模型,使用 Open Meta Analyst 进行 Meta 分析。此外,还进行了分组分析、元回归分析和敏感性分析:我们的分析纳入了八项研究,共有 26758 名 ALS 患者符合纳入标准。所有研究汇总的 VTE 年发病率为每千人年 22 例(95% CI = 18 至 27)。亚组分析显示,男性的 VTE 年发病率为每千人年 19 例(95% CI = 15 至 22),女性为每千人年 20 例(95% CI = 16 至 25)。剔除分析表明,当剔除每项研究时,发病率为每千人年 21 至 28 例。元回归分析未发现年龄与 VTE 风险之间存在显著关联(P = 0.079)。根据纳入的研究,ALS 患者发生 VTE 的风险因素包括 VTE 病史、无创通气、行动不便和功能状态下降:结论:与同龄人相比,ALS 患者发生 VTE 的风险更高。这些发现强调了对 ALS 患者实施预防措施和密切监测 VTE 的重要性。
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来源期刊
Tunisie Medicale
Tunisie Medicale Medicine-Medicine (all)
CiteScore
1.00
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0.00%
发文量
72
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