Effectiveness of laser therapy among patients with open-angle glaucoma: a systematic review and meta-analysis study.

IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL European Journal of Translational Myology Pub Date : 2024-10-22 DOI:10.4081/ejtm.2024.12931
Behzad Safarpour Lima, Shima Sayanjali
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Abstract

This study aims to evaluate the efficacy of selective laser trabeculoplasty in improving the intraocular pressure in patients diagnosed with open-angle glaucoma. A comprehensive search was performed across electronic databases, including PubMed, Scopus, and Web of Science, until June 2024, using keywords related to "selective laser trabeculoplasty" and "open-angle glaucoma." Studies were chosen based on set eligibility criteria. Data extraction was carried out by two independent reviewers, and statistical analyses were performed using a random-effects model to calculate the pooled mean differences in IOP reduction and overall success rates. The initial search yielded 3111 articles, with 23 studies included in the systematic review and 22 in the meta-analysis. The pooled MD in IOP reduction between the SLT and control groups was -1.44 mm Hg (95% CI: -2.19 to -0.70, p < 0.01). Subgroup analyses revealed a MD of -0.76 mm Hg (95% CI: -1.31 to -0.21, p < 0.01) when comparing SLT to medication, and -0.42 mm Hg (95% CI: -0.64 to -0.19, p < 0.01) when comparing 180-degree SLT to 360-degree SLT. The pooled success rate favored SLT with an odds ratio (OR) of 0.71 (95% CI: 0.51 to 0.99, p = 0.05). There was significant heterogeneity among the studies (I² = 71%). SLT is effective in lowering IOP in OAG patients, demonstrating significant efficacy compared to medication and different SLT protocols. The findings underscore SLT's potential as a reliable treatment option. However, the observed heterogeneity underscores the necessity for standardized protocols in future research to improve comparability and verify SLT's long-term effectiveness.

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激光疗法对开角型青光眼患者的疗效:一项系统回顾和荟萃分析研究。
本研究旨在评估选择性激光小梁成形术对改善开角型青光眼患者眼压的疗效。在 2024 年 6 月之前,我们使用与 "选择性激光小梁成形术 "和 "开角型青光眼 "相关的关键词在 PubMed、Scopus 和 Web of Science 等电子数据库中进行了全面检索。根据设定的资格标准选择研究。数据提取由两名独立审稿人完成,并使用随机效应模型进行统计分析,计算出眼压降低率和总体成功率的汇总平均差异。初步检索共获得 3111 篇文章,其中 23 项研究被纳入系统综述,22 项研究被纳入荟萃分析。SLT组和对照组之间眼压降低的总平均值为-1.44 mm Hg(95% CI:-2.19 至-0.70,p < 0.01)。亚组分析显示,SLT 与药物治疗相比,MD 为-0.76 毫米汞柱(95% CI:-1.31 至 -0.21,p < 0.01);180 度 SLT 与 360 度 SLT 相比,MD 为-0.42 毫米汞柱(95% CI:-0.64 至 -0.19,p < 0.01)。SLT的成功率为0.71(95% CI:0.51-0.99,P = 0.05)。各研究之间存在明显的异质性(I² = 71%)。SLT能有效降低OAG患者的眼压,与药物治疗和不同的SLT方案相比,疗效显著。研究结果凸显了 SLT 作为一种可靠治疗方案的潜力。然而,观察到的异质性强调了未来研究中标准化方案的必要性,以提高可比性并验证 SLT 的长期有效性。
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来源期刊
European Journal of Translational Myology
European Journal of Translational Myology MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.30
自引率
27.30%
发文量
74
审稿时长
10 weeks
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