[Critical alterations in the brain and psyche].

IF 0.9 4区 医学 Q4 CLINICAL NEUROLOGY Nervenarzt Pub Date : 2024-11-01 Epub Date: 2024-10-22 DOI:10.1007/s00115-024-01770-x
Manuel Brenner, Daniel Durstewitz
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Abstract

Critical alterations in the brain and psyche are often triggered by critical points and feedback effects in closely networked systems. Such crises can occur in the form of neurological disorders, such as epilepsy or mental disorders, such as bipolar disorder and depression. A central mechanism is the excitation-inhibition (EI) balance in the brain, which is responsible for an optimal processing of information. Disruptions in this balance can lead to pathological conditions. The concept of attractors, which represent the stable conditions in neuronal networks, helps to explain the consolidation of memories, behavioral patterns and mental states. These attractor states can be triggered by external stimuli and may become anchored in pathological contexts. Advances in measurement technologies and methods of artificial intelligence enable a deeper analysis of neuronal dynamics and open up new pathways for targeted therapeutic interventions for the treatment of mental disorders.

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[大脑和心理的重大变化]。
大脑和心理的严重变化往往是由紧密联网系统中的临界点和反馈效应引发的。这种危机可能以神经系统疾病(如癫痫)或精神障碍(如躁郁症和抑郁症)的形式出现。一个核心机制是大脑中的兴奋-抑制(EI)平衡,它负责对信息进行最佳处理。这种平衡的破坏会导致病理状况。吸引子的概念代表了神经元网络中的稳定状态,有助于解释记忆、行为模式和精神状态的巩固。这些吸引子状态可由外部刺激触发,并可能在病理环境中固定下来。测量技术和人工智能方法的进步有助于更深入地分析神经元动态,并为治疗精神障碍的靶向治疗干预开辟了新的途径。
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来源期刊
Nervenarzt
Nervenarzt 医学-精神病学
CiteScore
2.50
自引率
18.20%
发文量
169
审稿时长
4-8 weeks
期刊介绍: Der Nervenarzt is an internationally recognized journal addressing neurologists and psychiatrists working in clinical or practical environments. Essential findings and current information from neurology, psychiatry as well as neuropathology, neurosurgery up to psychotherapy are presented. Review articles provide an overview on selected topics and offer the reader a summary of current findings from all fields of neurology and psychiatry. Freely submitted original papers allow the presentation of important clinical studies and serve the scientific exchange. Review articles under the rubric ''Continuing Medical Education'' present verified results of scientific research and their integration into daily practice.
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