The Correlation between the Elastic Modulus of the Achilles Tendon Enthesis and Bone Microstructure in the Calcaneal Crescent.

IF 2.2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Tomography Pub Date : 2024-10-10 DOI:10.3390/tomography10100122

Kenichiro Doi, Dina Moazamian, Behnam Namiranian, Sheronda Statum, Amir Masoud Afsahi, Takuaki Yamamoto, Karen Y Cheng, Christine B Chung, Saeed Jerban

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Abstract

Background: The calcaneal enthesis, an osseous footprint where the Achilles tendon seamlessly integrates with the bone, represents a complex interface crucial for effective force transmission. Bone adapts to mechanical stress and remodels based on the applied internal and external forces. This study explores the relationship between the elasticity of the Achilles tendon enthesis and the bone microstructure in the calcaneal crescent.

Methods: In total, 19 calcaneal-enthesis sections, harvested from 10 fresh-frozen human cadaveric foot-ankle specimens (73.8 ± 6.0 years old, seven female), were used in this study. Indentation tests were performed at the enthesis region, and Hayes' elastic modulus was calculated for each specimen. Micro-CT scanning was performed at 50-micron voxel size to assess trabecular bone microstructure within six regions of interest (ROIs) and the cortical bone thickness along the calcaneal crescent.

Results: Significant Spearman correlations were observed between the enthesis elastic modulus and trabecular bone thickness in the distal entheseal (ROI 3) and proximal plantar (ROI 4) regions (R = 0.786 and 0.518, respectively).

Conclusion: This study highlights the potential impacts of Achilles tendon enthesis on calcaneal bone microstructure, which was pronounced in the distal calcaneal enthesis, suggesting regional differences in load transfer mechanism that require further investigation.

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跟腱假体弹性模量与跟骨新月骨微结构之间的相关性

背景：小腿内侧是跟腱与骨骼无缝结合的骨性足印，是一个复杂的界面，对有效的力传递至关重要。骨骼能适应机械应力，并根据施加的内外力进行重塑。本研究探讨了跟腱内侧的弹性与小腿新月骨微观结构之间的关系：本研究共使用了从 10 个新鲜冷冻的人体足踝尸体标本（73.8 ± 6.0 岁，女性 7 例）中采集的 19 个小腿骨假体切片。在内侧区域进行了压痕测试，并计算了每个标本的 Hayes 弹性模量。以 50 微米的体素大小进行显微 CT 扫描，以评估六个感兴趣区（ROI）内的骨小梁微观结构和沿小关节新月的皮质骨厚度：在远端胫骨内侧（ROI 3）和近端跖骨内侧（ROI 4）区域，内侧弹性模量与骨小梁厚度之间存在明显的斯皮尔曼相关性（R = 0.786 和 0.518）：本研究强调了跟腱内固定对小腿骨微观结构的潜在影响，这种影响在小腿骨远端内固定中尤为明显，表明负荷传递机制存在区域差异，需要进一步研究。

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来源期刊

Tomography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.70

自引率

10.50%

发文量

222

期刊介绍： TomographyTM publishes basic (technical and pre-clinical) and clinical scientific articles which involve the advancement of imaging technologies. Tomography encompasses studies that use single or multiple imaging modalities including for example CT, US, PET, SPECT, MR and hyperpolarization technologies, as well as optical modalities (i.e. bioluminescence, photoacoustic, endomicroscopy, fiber optic imaging and optical computed tomography) in basic sciences, engineering, preclinical and clinical medicine. Tomography also welcomes studies involving exploration and refinement of contrast mechanisms and image-derived metrics within and across modalities toward the development of novel imaging probes for image-based feedback and intervention. The use of imaging in biology and medicine provides unparalleled opportunities to noninvasively interrogate tissues to obtain real-time dynamic and quantitative information required for diagnosis and response to interventions and to follow evolving pathological conditions. As multi-modal studies and the complexities of imaging technologies themselves are ever increasing to provide advanced information to scientists and clinicians. Tomography provides a unique publication venue allowing investigators the opportunity to more precisely communicate integrated findings related to the diverse and heterogeneous features associated with underlying anatomical, physiological, functional, metabolic and molecular genetic activities of normal and diseased tissue. Thus Tomography publishes peer-reviewed articles which involve the broad use of imaging of any tissue and disease type including both preclinical and clinical investigations. In addition, hardware/software along with chemical and molecular probe advances are welcome as they are deemed to significantly contribute towards the long-term goal of improving the overall impact of imaging on scientific and clinical discovery.