Consideration of Antifungal Coverage in Treating Infections Related to Delayed Esophageal Perforation from Anterior Cervical Spine Hardware.

IF 3.4 Q2 INFECTIOUS DISEASES Infectious Disease Reports Pub Date : 2024-10-23 DOI:10.3390/idr16060082
Kavita Prasad, John Ceremsak, Jean-Nicolas Gallant, Hannah G Kay, Erin B Gettler, Benjamin R Campbell, Catherine R Carlile, Byron F Stephens, Sarah L Rohde, Patty W Wright, Christina T Fiske
{"title":"Consideration of Antifungal Coverage in Treating Infections Related to Delayed Esophageal Perforation from Anterior Cervical Spine Hardware.","authors":"Kavita Prasad, John Ceremsak, Jean-Nicolas Gallant, Hannah G Kay, Erin B Gettler, Benjamin R Campbell, Catherine R Carlile, Byron F Stephens, Sarah L Rohde, Patty W Wright, Christina T Fiske","doi":"10.3390/idr16060082","DOIUrl":null,"url":null,"abstract":"<p><p>(1) Background/Objectives: Delayed esophageal perforation following anterior cervical (spine) discectomy and fusion (ACDF) is rare but can lead to serious infectious complications. The treatment usually involves hardware explanation and prolonged intravenous antibiotics; however, there are scarce reports about the microbiology of these infections and corresponding targeted therapy. (2) Methods: Patients diagnosed or treated for delayed esophageal perforation after anterior cervical fusion between 2000-2020 at a tertiary medical center were studied. (3) Results: Seven patients with delayed esophageal perforation following ACDF were identified. The most common bacteria isolated included <i>Streptococcus</i>, <i>Haemophilus</i>, and <i>Mycobacterium</i> species. The cultures from five patients grew fungal species, including <i>Candida albicans</i> and <i>C. glabrata</i>. All the patients received several weeks of broad-spectrum antibiotics, and, notably, 5/7 patients received antifungal therapy targeting <i>Candida</i>. (4) Conclusions: Although the incidence of delayed esophageal perforation following ACDF is low, providers should remain aware of this entity due to the serious infectious complications. Most infections are polymicrobial in nature, and providers should consider empiric antifungal coverage specifically targeting <i>Candida</i> species when treating patients with this complication.</p>","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503398/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious Disease Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/idr16060082","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

Abstract

(1) Background/Objectives: Delayed esophageal perforation following anterior cervical (spine) discectomy and fusion (ACDF) is rare but can lead to serious infectious complications. The treatment usually involves hardware explanation and prolonged intravenous antibiotics; however, there are scarce reports about the microbiology of these infections and corresponding targeted therapy. (2) Methods: Patients diagnosed or treated for delayed esophageal perforation after anterior cervical fusion between 2000-2020 at a tertiary medical center were studied. (3) Results: Seven patients with delayed esophageal perforation following ACDF were identified. The most common bacteria isolated included Streptococcus, Haemophilus, and Mycobacterium species. The cultures from five patients grew fungal species, including Candida albicans and C. glabrata. All the patients received several weeks of broad-spectrum antibiotics, and, notably, 5/7 patients received antifungal therapy targeting Candida. (4) Conclusions: Although the incidence of delayed esophageal perforation following ACDF is low, providers should remain aware of this entity due to the serious infectious complications. Most infections are polymicrobial in nature, and providers should consider empiric antifungal coverage specifically targeting Candida species when treating patients with this complication.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
在治疗与颈椎前路硬件延迟性食管穿孔相关的感染时考虑使用抗真菌药物。
(1) 背景/目的:颈椎(脊柱)前路椎间盘切除和融合术(ACDF)后延迟性食管穿孔非常罕见,但可导致严重的感染并发症。治疗方法通常包括硬件解释和长期静脉注射抗生素;然而,有关这些感染的微生物学和相应的针对性治疗的报道却很少。(2)方法:研究对象为 2000-2020 年间在一家三级医疗中心诊断或治疗颈椎前路融合术后延迟性食管穿孔的患者。(3)结果:共发现 7 例 ACDF 术后延迟性食管穿孔患者。分离出的最常见细菌包括链球菌、嗜血杆菌和分枝杆菌。五名患者的培养物中生长出真菌,包括白色念珠菌和光滑念珠菌。所有患者都接受了数周的广谱抗生素治疗,值得注意的是,5/7 的患者接受了针对白色念珠菌的抗真菌治疗。(4) 结论:尽管 ACDF 术后延迟性食管穿孔的发生率很低,但由于其严重的感染性并发症,医疗服务提供者仍应保持警惕。大多数感染都是多菌性的,医疗机构在治疗这种并发症的患者时应考虑经验性抗真菌治疗,特别是针对念珠菌的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Infectious Disease Reports
Infectious Disease Reports INFECTIOUS DISEASES-
CiteScore
5.10
自引率
0.00%
发文量
82
审稿时长
11 weeks
期刊最新文献
Consideration of Antifungal Coverage in Treating Infections Related to Delayed Esophageal Perforation from Anterior Cervical Spine Hardware. The Cumulative Variations of Respiratory Syncytial Virus Fusion Protein (F) in Ten Consecutive Years in China. Progressive Thoracolumbar Tuberculosis in a Young Male: Diagnostic, Therapeutic, and Surgical Insights. Gallbladder Burkitt's Lymphoma: A Literature Review Including a Case Report in a Child Living with HIV. Investigation of the Effect of the COVID-19 Pandemic Period on Respiratory Tract Viruses at Istanbul Medical Faculty Hospital, Turkey.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1