Methylene Blue: An FDA-Approved NIR-II Fluorogenic Probe with Extremely Low pH Responsibility for Hyperchlorhydria Imaging

Chemical & Biomedical Imaging Pub Date : 2024-04-12 DOI:10.1021/cbmi.4c0001110.1021/cbmi.4c00011

Guanjun Deng, Siwei Zhang, Xinghua Peng, Gongcheng Ma, Luxuan Liu, Yuyu Tan, Ping Gong*, Ben Zhong Tang*, Lintao Cai* and Pengfei Zhang*,

引用次数: 0

Abstract

Methylene blue (MB) is an FDA (Food and Drug Administration)-approved contrast agent with donor–acceptor (D–A) structure integrated with carbonyl-containing nitrogen-heterocycles. MB can be converted into MBH (protonated MB) by protonation, which not only induces the fluorescence emission red-shifted from the first near-infrared window (NIR-I, 650–950 nm) to the second near-infrared window (NIR-II, 1000–1700 nm) but also achieves ACQ-to-AIE conversion. MB has been successfully demonstrated in hyperacidemia imaging with an extremely low pH value (<1).

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亚甲基蓝：用于高氯酸血症成像的 FDA 批准的具有极低 pH 值的 NIR-II 荧光探针

亚甲基蓝（MB）是一种经美国食品和药物管理局（FDA）批准的造影剂，其供体-受体（D-A）结构与含羰基的氮杂环结合在一起。MB 可通过质子化转化为 MBH（质子化 MB），这不仅会导致荧光发射从第一近红外窗口（NIR-I，650-950 nm）红移到第二近红外窗口（NIR-II，1000-1700 nm），还能实现 ACQ 到 AIE 的转化。MB 已成功应用于 pH 值极低的高血脂症成像（<1）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Chemical & Biomedical Imaging 化学与生物成像-

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1.00

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0.00%

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期刊介绍： Chemical & Biomedical Imaging is a peer-reviewed open access journal devoted to the publication of cutting-edge research papers on all aspects of chemical and biomedical imaging. This interdisciplinary field sits at the intersection of chemistry physics biology materials engineering and medicine. The journal aims to bring together researchers from across these disciplines to address cutting-edge challenges of fundamental research and applications.Topics of particular interest include but are not limited to:Imaging of processes and reactionsImaging of nanoscale microscale and mesoscale materialsImaging of biological interactions and interfacesSingle-molecule and cellular imagingWhole-organ and whole-body imagingMolecular imaging probes and contrast agentsBioluminescence chemiluminescence and electrochemiluminescence imagingNanophotonics and imagingChemical tools for new imaging modalitiesChemical and imaging techniques in diagnosis and therapyImaging-guided drug deliveryAI and machine learning assisted imaging

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