Synthesis and anti-inflammatory activity of N-substituted 4-aryl-2-[(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino]-4-oxobut-2-enamides

Abstract

Synthesis of N-substituted 4-aryl-2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxobut-2-enamides by the reaction of the substituted 2-[(5-aryl-2-oxofuran-3(2H)-ylidene)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitriles with primary amines was developed. Anti-inflammatory activity and acute toxicity of the synthesized compounds were examined. It was found that the synthesized compounds possess pronounced anti-inflammatory activity and low toxicity. According to the classification of toxicity of drugs, the synthesized amides belong to toxicity class V of practically nontoxic substances.