Comparative Side-Effects of Neurosurgical Treatment of Treatment-Resistant Depression

IF 4.8 1区医学 Q1 NEUROSCIENCES CNS Neuroscience & Therapeutics Pub Date : 2024-10-28 DOI:10.1111/cns.70090

Alexandre Lim Eng Keat, Keith Tan Jian Li, Teo Chuin Hau, Tomoko Soga

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Abstract

Introduction

Treatment-resistant depression (TRD) is a condition in which patients suffering from depression no longer respond to common methods of treatment, such as anti-depressant medication. Neurosurgical procedures such as ablative surgery, deep brain stimulation, and vagus nerve stimulation have been used in efforts to overcome TRD.

Objectives

This review aims to provide an overview of the side effects of neurosurgery performed in clinical studies related to depression.

Methods

A literature search was conducted through PubMed, MEDLINE, EMBASE, Ovid, and ClinicalTrials.gov databases.

Results

This review selected 10 studies for ablative surgery, 12 for deep brain stimulation, and 10 for vagus nerve stimulation, analyzing their side effect profiles of neurosurgery for TRD. The major side effects of each type of neurosurgery were identified, such as incontinence and confusion for ablative surgery, headaches and increased suicide ideation for deep brain stimulation, and voice hoarseness and dyspnea for vagus nerve stimulation.

Conclusion

The review discusses the merits and demerits of neurosurgery as a treatment option for TRD. It also suggests new insights into decreasing the burden of these neurosurgical side effects so that they can be a viable, high-efficacy treatment method for TRD.

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神经外科治疗难治性抑郁症的副作用比较。

导言：抗药性抑郁症（TRD）是指抑郁症患者对抗抑郁药物等普通治疗方法不再产生反应。神经外科手术，如消融手术、脑深部刺激和迷走神经刺激，已被用于克服 TRD：本综述旨在概述抑郁症相关临床研究中进行的神经外科手术的副作用：方法：通过PubMed、MEDLINE、EMBASE、Ovid和ClinicalTrials.gov数据库进行文献检索：本综述选取了10项消融手术研究、12项脑深部刺激研究和10项迷走神经刺激研究，分析了神经外科手术治疗TRD的副作用。确定了每种神经外科手术的主要副作用，如消融手术的尿失禁和精神错乱，深部脑刺激的头痛和自杀意念增强，迷走神经刺激的声音嘶哑和呼吸困难：本综述讨论了神经外科手术作为 TRD 治疗选择的优缺点。结论：这篇综述讨论了神经外科手术作为 TRD 治疗方法的优缺点，并就如何减轻这些神经外科副作用的负担提出了新的见解，从而使神经外科手术成为 TRD 的一种可行、高效的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.