177 Lu-PSMA-617 Radioligand Therapy in Patient With Prostate Cancer Sciatic Nerve Metastasis.

IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Clinical Nuclear Medicine Pub Date : 2024-12-01 Epub Date: 2024-10-14 DOI:10.1097/RLU.0000000000005503
David Tonnelet, Agathe Edet-Sanson, Laetitia Augusto, Marine Cabourg, Sébastien Thureau
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Abstract

Abstract: Patients with metastatic castration-resistant prostate cancer usually have lymph nodes and bone metastasis. We present a rare case of a 51-year-old patient with metastatic castration-resistant prostate cancer who complained of left truncated sciatica and diffuse bone pain and who was referred for 177 Lu-prostate-specific membrane antigen (PSMA) screening. Pretreatment 68 Ga-PSMA showed left sciatic nerve and multiple bone uptake. Patient underwent stereotactic radiotherapy on the sciatic nerve metastasis (30 Gy in 6 fractions of 5 Gy) before 7.4 GBq of 177 Lu-PSMA infusions. Left truncated sciatica disappeared after stereotactic radiotherapy. No additional toxicity was added to the sciatic nerve from 177 Lu-PSMA after stereotactic radiotherapy.

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前列腺癌坐骨神经转移患者的 177Lu-PSMA-617 放射配体疗法
摘要:转移性耐受性前列腺癌患者通常有淋巴结和骨转移。我们报告了一例罕见的病例:51 岁的转移性耐受性前列腺癌患者主诉左侧截断性坐骨神经痛和弥漫性骨痛,并被转诊接受 177Lu 前列腺特异性膜抗原(PSMA)筛查。治疗前 68Ga-PSMA 显示左侧坐骨神经和多处骨摄取。患者在接受 7.4 GBq 的 177Lu-PSMA 输注之前,对坐骨神经转移灶进行了立体定向放疗(30 Gy,6 次 5 Gy)。立体定向放疗后,左侧截断性坐骨神经痛消失。立体定向放射治疗后,177Lu-PSMA 对坐骨神经没有产生额外的毒性。
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来源期刊
Clinical Nuclear Medicine
Clinical Nuclear Medicine 医学-核医学
CiteScore
2.90
自引率
31.10%
发文量
1113
审稿时长
2 months
期刊介绍: Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.
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