Prevalence of immunoglobulin E sensitisation to mites and pollens in 25,451 French dogs from 2016 to 2022.

IF 1.9 3区 农林科学 Q3 DERMATOLOGY Veterinary dermatology Pub Date : 2024-10-29 DOI:10.1111/vde.13309
Laurent Drouet, Silvia Bonati, Alicia Cozar, Nathalie Petit, Pascal Prélaud
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Abstract

Background: Canine atopic dermatitis (cAD) is a common skin disorder in dogs, wherein allergens are presumed to exert a significant influence. The prevalence of allergen sensitisation in dogs with suspected cAD remains inadequately investigated in France.

Hypothesis/objectives: This study aimed to analyse allergen-specific immunoglobulin (Ig)E test results from French dogs with suspected cAD, exploring potential risk factors influencing sensitisation.

Animals: The study included 25,451 client-owned dogs presented with clinical signs of cAD between January 2016 and December 2022. The study population consisted of 226 pure breeds and 915 cross-bred dogs of both sexes, with a mean age of 4.4 (±2.8) years.

Materials and methods: Data collection involved the compilation of results from canine serological allergen-specific IgE ELISA tests, using a 23 allergen composite panel. The influence of breed, sex, age, geographical area and sampling season on IgE test outcomes subsequently was analysed.

Results: Of the 25,451 analysed samples, 75.6% exhibited significant serum IgE concentrations in response to at least one of the tested allergens, with 67.9% testing positive for mites and 39.8% for pollens. Breed, sex, age, geographical area and sampling season were identified as significant risk factors influencing sensitisation patterns.

Conclusions and clinical relevance: This study provides insights into the prevalence and risk factors associated with allergen sensitisation in dogs with suspected cAD. Understanding these factors is crucial for effective diagnosis and tailored management strategies in veterinary practice. The findings underscore the need for personalised approaches in addressing cAD, considering individual patient characteristics.

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2016 年至 2022 年期间,25451 只法国狗对螨虫和花粉过敏的免疫球蛋白 E 的流行率。
背景:犬特应性皮炎(cAD)是一种常见的犬皮肤病,据推测过敏原对其有很大影响。在法国,对患有疑似 cAD 的狗的过敏原致敏率的调查仍然不足:本研究旨在分析法国疑似 cAD 患犬的过敏原特异性免疫球蛋白 (Ig)E 检测结果,探索影响过敏的潜在风险因素:研究对象包括2016年1月至2022年12月期间出现cAD临床症状的25451只客户饲养的犬只。研究对象包括 226 只纯种犬和 915 只杂交犬,雌雄均有,平均年龄为 4.4 (±2.8) 岁:数据收集包括犬血清过敏原特异性 IgE 酶联免疫吸附试验结果的汇编,该试验使用 23 种过敏原复合面板。随后分析了品种、性别、年龄、地理区域和采样季节对 IgE 检测结果的影响:结果:在 25 451 份分析样本中,75.6% 的样本对至少一种测试过敏原表现出明显的血清 IgE 浓度,其中 67.9% 的样本对螨虫测试呈阳性,39.8% 的样本对花粉测试呈阳性。品种、性别、年龄、地理区域和采样季节被认为是影响过敏模式的重要风险因素:这项研究有助于深入了解疑似 cAD 患犬过敏原致敏的发生率和相关风险因素。了解这些因素对于兽医实践中的有效诊断和量身定制的管理策略至关重要。研究结果强调,在处理 cAD 时需要考虑患者的个体特征,采取个性化的方法。
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来源期刊
Veterinary dermatology
Veterinary dermatology 农林科学-兽医学
CiteScore
3.20
自引率
21.40%
发文量
92
审稿时长
12-24 weeks
期刊介绍: Veterinary Dermatology is a bi-monthly, peer-reviewed, international journal which publishes papers on all aspects of the skin of mammals, birds, reptiles, amphibians and fish. Scientific research papers, clinical case reports and reviews covering the following aspects of dermatology will be considered for publication: -Skin structure (anatomy, histology, ultrastructure) -Skin function (physiology, biochemistry, pharmacology, immunology, genetics) -Skin microbiology and parasitology -Dermatopathology -Pathogenesis, diagnosis and treatment of skin diseases -New disease entities
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