Molecular mechanisms of the obesity associated with Bardet-Biedl syndrome: An update.

IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Reviews Pub Date : 2024-10-30 DOI:10.1111/obr.13859
Bang-Hua Zhong, Ning Nie, Ming Dong
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Abstract

Obesity is a prominent feature of Bardet-Biedl syndrome (BBS), which represents a major and growing public health problem. More than half of BBS patients carry mutations in one of eight genes that encode subunits of a protein complex known as the BBSome, which has emerged as a key regulator of energy and glucose homeostasis. However, the mechanisms underlying obesity in BBS are complex. Numerous studies have identified a high prevalence of insulin resistance and metabolic syndrome among individuals with BBS. However, the exact mechanisms are not fully understood. This review summarized evidence from experiments using mouse and cell models, focusing on the energy imbalance that leads to obesity in patients with BBS. The studies discussed in this review contribute to understanding the functional role of the BBSome in the obesity associated with BBS, laying the foundation for developing new preventive or therapeutic strategies for obese patients.

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与巴尔德-比德尔综合征相关的肥胖症的分子机制:最新进展。
肥胖是巴尔德-比德尔综合征(BBS)的一个显著特征,它是一个日益严重的重大公共健康问题。半数以上的 BBS 患者携带 8 个基因中的一个基因突变,这些基因编码一种被称为 BBSome 的蛋白质复合体的亚基,而 BBSome 已成为能量和葡萄糖平衡的关键调节因子。然而,BBS 导致肥胖的机制非常复杂。大量研究发现,BBS 患者中胰岛素抵抗和代谢综合征的发病率很高。然而,确切的机制还不完全清楚。本综述总结了使用小鼠和细胞模型进行实验的证据,重点关注导致 BBS 患者肥胖的能量失衡。本综述中讨论的研究有助于了解 BBSome 在与 BBS 相关的肥胖症中的功能作用,从而为肥胖症患者制定新的预防或治疗策略奠定基础。
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来源期刊
Obesity Reviews
Obesity Reviews 医学-内分泌学与代谢
CiteScore
19.30
自引率
1.10%
发文量
130
审稿时长
1 months
期刊介绍: Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities. Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field. The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.
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