A Case of Syphilis With Ocular Involvement: Persistent Negative Serology in a Patient With Multiple Sclerosis.

IF 3.8 4区 医学 Q2 IMMUNOLOGY Open Forum Infectious Diseases Pub Date : 2024-10-29 eCollection Date: 2024-10-01 DOI:10.1093/ofid/ofae563
Luca Pipitò, Irene Ganci, Andrea Cicero, Alice Annalisa Medaglia, Simona D'Avenia, Edoardo Mandalà, Cinzia Calà, Paola Di Carlo, Antonio Cascio
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Abstract

Diagnostic algorithms for syphilis are based on serology. However, with the advent of immunosuppressive therapies, these algorithms may fail. We report a case of an individual with multiple sclerosis on treatment with ofatumumab and secondary syphilis with visual and auditory systems involvement and persistent negative treponemal and nontreponemal tests.

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一例眼部受累的梅毒患者:多发性硬化症患者血清持续阴性。
梅毒的诊断算法以血清学为基础。然而,随着免疫抑制疗法的出现,这些算法可能会失效。我们报告了一例多发性硬化症患者的病例,患者在接受ofatumumab治疗后出现继发性梅毒,视觉和听觉系统受累,特雷波及非特雷波及梅毒试验持续阴性。
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来源期刊
Open Forum Infectious Diseases
Open Forum Infectious Diseases Medicine-Neurology (clinical)
CiteScore
6.70
自引率
4.80%
发文量
630
审稿时长
9 weeks
期刊介绍: Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.
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