New perspectives of exosomes in urologic malignancies – Mainly focus on biomarkers and tumor microenvironment

IF 2.9 4区医学 Q2 PATHOLOGY Pathology, research and practice Pub Date : 2024-11-01 DOI:10.1016/j.prp.2024.155645

{"title":"New perspectives of exosomes in urologic malignancies – Mainly focus on biomarkers and tumor microenvironment","authors":"","doi":"10.1016/j.prp.2024.155645","DOIUrl":null,"url":null,"abstract":"<div><div>Bladder cancer (BCa) and renal cell carcinoma (RCC) are prevalent urologic malignancies (UM) characterized by high morbidity and frequent recurrence. Current diagnostic approaches, often invasive, often indicate an advanced disease stage. And the complex tumor microenvironment often promotes tumor progression and induces resistance to chemotherapy. Current diagnostic and therapeutic modalities often fail to achieve satisfactory outcomes for patients. Exosomes transport diverse cargoes, including cytokines, proteins, lipids, non-coding RNAs, and microRNAs, crucial for intercellular communication. Exosomes have shown potential as biomarkers for UM, participating in tumor progression, especially within the tumor microenvironment (TME), including tumor cell apoptosis, proliferation, migration, invasion, depletion of immune cell function, epithelial-mesenchymal transition (EMT), angiogenesis, and more.In this review, we summarize research advances related to exosomes in UM, focusing on the role of exosomes as biomarkers in bladder and renal cancer, highlighting their significance within the TME.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathology, research and practice","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0344033824005569","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Bladder cancer (BCa) and renal cell carcinoma (RCC) are prevalent urologic malignancies (UM) characterized by high morbidity and frequent recurrence. Current diagnostic approaches, often invasive, often indicate an advanced disease stage. And the complex tumor microenvironment often promotes tumor progression and induces resistance to chemotherapy. Current diagnostic and therapeutic modalities often fail to achieve satisfactory outcomes for patients. Exosomes transport diverse cargoes, including cytokines, proteins, lipids, non-coding RNAs, and microRNAs, crucial for intercellular communication. Exosomes have shown potential as biomarkers for UM, participating in tumor progression, especially within the tumor microenvironment (TME), including tumor cell apoptosis, proliferation, migration, invasion, depletion of immune cell function, epithelial-mesenchymal transition (EMT), angiogenesis, and more.In this review, we summarize research advances related to exosomes in UM, focusing on the role of exosomes as biomarkers in bladder and renal cancer, highlighting their significance within the TME.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

外泌体在泌尿系统恶性肿瘤中的新视角--主要关注生物标记物和肿瘤微环境。

膀胱癌（BCa）和肾细胞癌（RCC）是流行的泌尿系统恶性肿瘤（UM），其特点是发病率高且经常复发。目前的诊断方法通常为侵入性诊断，往往提示疾病已进入晚期。而复杂的肿瘤微环境往往会促进肿瘤进展并诱发对化疗的耐药性。目前的诊断和治疗方法往往无法为患者带来满意的结果。外泌体可运输多种货物，包括细胞因子、蛋白质、脂质、非编码 RNA 和 microRNA，它们对细胞间的交流至关重要。外泌体已显示出作为泌尿系统肿瘤生物标志物的潜力，参与肿瘤的进展，尤其是在肿瘤微环境（TME）中，包括肿瘤细胞凋亡、增殖、迁移、侵袭、免疫细胞功能耗竭、上皮-间质转化（EMT）、血管生成等。在这篇综述中，我们总结了泌尿系统肿瘤中外泌体的相关研究进展，重点介绍了外泌体作为生物标志物在膀胱癌和肾癌中的作用，并强调了它们在TME中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.