MTHFR C677T、MTHFR A1298C、MTRR A66G and MTR A2756G polymorphisms and male infertility risk: a systematic review and meta-analysis.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Reproductive Biology and Endocrinology Pub Date : 2024-10-30 DOI:10.1186/s12958-024-01306-7

Feng Li, Ju-Ju Qi, Li-Xin Li, Teng-Fei Yan

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Abstract

Background: Epidemiological studies have reported that polymorphisms of folate-metabolizing genes have a significant impact on male infertility. However, the results of published studies have come to different conclusions.

Objective: To determine an association between folate-metabolizing gene polymorphisms and the risk of male infertility.

Methods: The meta-analysis was conducted according to the PRISMA 2020 statement. The protocol was registered with PROSPERO (CRD42023412251). Studies were searched from PubMed, Google Scholar, Embase, Scopus, and the Cochrane Library up to 24st October2023. Articles that satisfied the inclusion criteria were evaluated for their quality using the Newcastle-Ottawa Scale. Data were extracted from the eligible studies and were analyzed for pooled up odds ratio (OR) with 95% confidence interval (CI). Meta-analysis was conducted using STATA 12.

Results: Forty-six case-control studies were included in the meta-analysis which comprised 20,639 participants. The pooled analysis revealed that the MTHFR C677T polymorphism was significantly associated with male infertility and abnormospermia.Three-fifths of the model showed there was a significant association between the MTR A2756G polymorphism and male infertility. Both MTHFR A1298C and MTRR A66G polymorphisms were not significantly associated with male fertility. Furthermore, subgroup analysis revealed a significant association between the MTHFR C677T polymorphism and male fertility in Asian countries.

Conclusion: This meta-analysis suggests that the MTHFR C677T and MTR A2756G polymorphisms may be a potential risk factor for male infertility.

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MTHFR C677T、MTHFR A1298C、MTRR A66G 和 MTR A2756G 多态性与男性不育风险：系统综述和荟萃分析。

背景：流行病学研究表明，叶酸代谢基因的多态性对男性不育症有重要影响。然而，已发表的研究结果却得出了不同的结论：确定叶酸代谢基因多态性与男性不育风险之间的关联：荟萃分析根据PRISMA 2020声明进行。研究方案已在 PROSPERO（CRD42023412251）注册。截至 2023 年 10 月 24 日，在 PubMed、Google Scholar、Embase、Scopus 和 Cochrane 图书馆检索了相关研究。采用纽卡斯尔-渥太华量表对符合纳入标准的文章进行质量评估。从符合条件的研究中提取数据，分析汇集起来的几率比（OR）和 95% 的置信区间（CI）。使用 STATA 12 进行 Meta 分析：荟萃分析纳入了 46 项病例对照研究，共有 20639 名参与者。汇总分析结果显示，MTHFR C677T 多态性与男性不育和精子异常显著相关。MTHFR A1298C 和 MTRR A66G 多态性与男性不育无明显关联。此外，亚组分析显示，在亚洲国家，MTHFR C677T 多态性与男性生育力之间存在显著关联：这项荟萃分析表明，MTHFR C677T 和 MTR A2756G 多态性可能是导致男性不育的潜在风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Biology and Endocrinology 医学-内分泌学与代谢

CiteScore

7.90

自引率

2.30%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.