Pathogenesis and research progress of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY World Journal of Hepatology Pub Date : 2024-10-27 DOI:10.4254/wjh.v16.i10.1142
Guan-Yue Shan, Hui Wan, Yu-Xin Zhang, Jun-Ya Cheng, Duan-Rui Qiao, Yi-Ying Liu, Wen-Na Shi, Hai-Jun Li
{"title":"Pathogenesis and research progress of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.","authors":"Guan-Yue Shan, Hui Wan, Yu-Xin Zhang, Jun-Ya Cheng, Duan-Rui Qiao, Yi-Ying Liu, Wen-Na Shi, Hai-Jun Li","doi":"10.4254/wjh.v16.i10.1142","DOIUrl":null,"url":null,"abstract":"<p><p>In this editorial, we comment on the article by Mei <i>et al</i>. Nonalcoholic steatohepatitis (NASH) is a severe inflammatory subtype of nonalcoholic fatty liver disease (NAFLD) with pathological features including steatosis, hepatocellular damage, and varying degrees of fibrosis. With the epidemic of metabolic diseases and obesity, the prevalence of NAFLD in China has increased, and it is now similar to that in developed countries; thus, NAFLD has become a major chronic liver disease in China. Human epidemiological data suggest that estrogen has a protective effect on NASH in premenopausal women and that sex hormones influence the development of liver disease. This review focuses on the pathogenesis, treatment, and relationship between NASH and other diseases as well as on the relationship between NASH and sex hormone metabolism, with the aim of providing new strategies for the treatment of NASH.</p>","PeriodicalId":23687,"journal":{"name":"World Journal of Hepatology","volume":"16 10","pages":"1142-1150"},"PeriodicalIF":2.5000,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514618/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4254/wjh.v16.i10.1142","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

In this editorial, we comment on the article by Mei et al. Nonalcoholic steatohepatitis (NASH) is a severe inflammatory subtype of nonalcoholic fatty liver disease (NAFLD) with pathological features including steatosis, hepatocellular damage, and varying degrees of fibrosis. With the epidemic of metabolic diseases and obesity, the prevalence of NAFLD in China has increased, and it is now similar to that in developed countries; thus, NAFLD has become a major chronic liver disease in China. Human epidemiological data suggest that estrogen has a protective effect on NASH in premenopausal women and that sex hormones influence the development of liver disease. This review focuses on the pathogenesis, treatment, and relationship between NASH and other diseases as well as on the relationship between NASH and sex hormone metabolism, with the aim of providing new strategies for the treatment of NASH.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
非酒精性脂肪肝/非酒精性脂肪性肝炎的发病机制和研究进展。
非酒精性脂肪性肝炎(NASH)是非酒精性脂肪性肝病(NAFLD)的一种严重炎症亚型,其病理特征包括脂肪变性、肝细胞损伤和不同程度的肝纤维化。随着代谢性疾病和肥胖症的流行,非酒精性脂肪肝在中国的发病率不断上升,目前已与发达国家相近,非酒精性脂肪肝已成为中国的主要慢性肝病。人类流行病学数据表明,雌激素对绝经前妇女的非酒精性脂肪肝有保护作用,性激素影响肝病的发生发展。本综述主要探讨非酒精性脂肪肝的发病机制、治疗、与其他疾病的关系以及非酒精性脂肪肝与性激素代谢的关系,以期为非酒精性脂肪肝的治疗提供新的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
World Journal of Hepatology
World Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.10
自引率
4.20%
发文量
172
期刊最新文献
Chronic hepatitis B: Prevent, diagnose, and treat before the point of no return. Complement activation targeted inhibitor C2-FH ameliorates acetaminophen-induced liver injury in mice. Hepatitis B surface antigen-negative but hepatitis B envelope antigen-positive false occult hepatitis B virus infection: A case report. Liver cell cancer surveillance practice in Nigeria: Pitfalls and future prospects. Pathogenesis and research progress of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1