Pathogenesis and research progress of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY World Journal of Hepatology Pub Date : 2024-10-27 DOI:10.4254/wjh.v16.i10.1142
Guan-Yue Shan, Hui Wan, Yu-Xin Zhang, Jun-Ya Cheng, Duan-Rui Qiao, Yi-Ying Liu, Wen-Na Shi, Hai-Jun Li
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Abstract

In this editorial, we comment on the article by Mei et al. Nonalcoholic steatohepatitis (NASH) is a severe inflammatory subtype of nonalcoholic fatty liver disease (NAFLD) with pathological features including steatosis, hepatocellular damage, and varying degrees of fibrosis. With the epidemic of metabolic diseases and obesity, the prevalence of NAFLD in China has increased, and it is now similar to that in developed countries; thus, NAFLD has become a major chronic liver disease in China. Human epidemiological data suggest that estrogen has a protective effect on NASH in premenopausal women and that sex hormones influence the development of liver disease. This review focuses on the pathogenesis, treatment, and relationship between NASH and other diseases as well as on the relationship between NASH and sex hormone metabolism, with the aim of providing new strategies for the treatment of NASH.

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非酒精性脂肪肝/非酒精性脂肪性肝炎的发病机制和研究进展。
非酒精性脂肪性肝炎(NASH)是非酒精性脂肪性肝病(NAFLD)的一种严重炎症亚型,其病理特征包括脂肪变性、肝细胞损伤和不同程度的肝纤维化。随着代谢性疾病和肥胖症的流行,非酒精性脂肪肝在中国的发病率不断上升,目前已与发达国家相近,非酒精性脂肪肝已成为中国的主要慢性肝病。人类流行病学数据表明,雌激素对绝经前妇女的非酒精性脂肪肝有保护作用,性激素影响肝病的发生发展。本综述主要探讨非酒精性脂肪肝的发病机制、治疗、与其他疾病的关系以及非酒精性脂肪肝与性激素代谢的关系,以期为非酒精性脂肪肝的治疗提供新的策略。
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来源期刊
World Journal of Hepatology
World Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.10
自引率
4.20%
发文量
172
期刊最新文献
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