[Research Advances of Exosomes in Pathogenesis of Multiple Myeloma --Review].

Xin-Yue Lang, Qiu-Rong Zhang, Jin-Ge Xu
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引用次数: 0

Abstract

Research on the participation of exosomes in pathogenesis and prognosis of multiple myeloma (MM) has made encouraging progress. However, the specific mechanism has not yet been clarified. Recently, domestic and foreign researchers have pressed forward on deeper study on exosomes. This article mainly summarizes the role of exosomes in the pathophysiological processes, such as bone marrow microenvironment changes, immunosuppression, myeloma bone disease generation and myeloma drug resistance, so as to provide new reference for further clinical research of exosomes as potential biomarkers for MM.

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[外泌体在多发性骨髓瘤发病机制中的研究进展--综述]。
关于外泌体参与多发性骨髓瘤(MM)发病机制和预后的研究取得了令人鼓舞的进展。但其具体机制尚未明确。近年来,国内外研究人员对外泌体的研究不断深入。本文主要总结了外泌体在骨髓微环境改变、免疫抑制、骨髓瘤骨病生成和骨髓瘤耐药等病理生理过程中的作用,从而为进一步开展外泌体作为MM潜在生物标志物的临床研究提供新的参考。
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来源期刊
中国实验血液学杂志
中国实验血液学杂志 Medicine-Medicine (all)
CiteScore
0.40
自引率
0.00%
发文量
7331
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[Effect and Influencing Factors of Peripheral Blood Hematopoietic Stem Cells Collection from Unrelated Donors]. [Effect of Endothelial Activation and Stress Index(EASIX) on Prognosis of Peripheral T-Cell Lymphoma Patient]. [Effect of JMJD3-IRF4 Signaling Pathway-Mediated Macrophage Polarization on the Malignant Biological Behavior of Multiple Myeloma Cells]. [Effect of Tumor Suppressor Gene Kmt2c Heterozygous Deletion on Hematopoietic System in Mice]. [Effects of ATG5 and ATG7 Knockout on Ferroptosis Sensitivity of RPMI-8226 Cells].
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