Efficacy of dextrose prolotherapy for temporomandibular joint hypermobility: A systematic review and meta-analysis.

IF 2 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Cranio-The Journal of Craniomandibular & Sleep Practice Pub Date : 2024-10-29 DOI:10.1080/08869634.2024.2419845

Gehong Zhou, Yingshun Hu, Sumin Wang

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Abstract

Objective: We reviewed the efficacy of dextrose prolotherapy versus placebo and other active interventions, like autologous blood injection (ABI) and botulinum toxin (BTX), in improving the outcomes of temporomandibular joint (TMJ) hypermobility.

Methods: We searched PubMed, the Cochrane CENTRAL library, Embase, Scopus, and Web of Science databases to identify randomized controlled trials (RCTs) . Maximal mouth opening (MMO), pain, and frequency of dislocations were analyzed.

Results: Eight RCTs were included. In comparison with placebo, dextrose prolotherapy was associated with significantly reduced pain and MMO. Comparison of dextrose with ABI revealed no significant difference in MMO. Qualitative analysis showed no significant difference in outcomes in patients who received dextrose prolotherapy and BTX.

Conclusions: Low-quality evidence suggests that dextrose prolotherapy may reduce MMO and improve pain scores compared to placebo in patients with TMJ hypermobility. Low-quality evidence also suggests that there may be minimal difference in outcomes between dextrose vs ABI and BTX.

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葡萄糖增生疗法对颞下颌关节过度活动症的疗效：系统回顾与荟萃分析。

目的：我们回顾了葡萄糖增生疗法与安慰剂和其他积极干预措施（如自体血液注射（ABI）和肉毒杆菌毒素（BTX））在改善颞下颌关节（TMJ）过度活动症疗效方面的对比：我们检索了 PubMed、Cochrane CENTRAL 图书馆、Embase、Scopus 和 Web of Science 数据库，以确定随机对照试验 (RCT)。对最大张口度（MMO）、疼痛和脱位频率进行了分析：结果：共纳入 8 项随机对照试验。与安慰剂相比，葡萄糖增殖疗法可显著减轻疼痛和最大张口度。葡萄糖与 ABI 的比较显示，MMO 没有明显差异。定性分析显示，接受葡萄糖增殖疗法和BTX治疗的患者在疗效上无明显差异：低质量证据表明，与安慰剂相比，葡萄糖增殖疗法可减少颞下颌关节过度活动患者的MMO并改善疼痛评分。低质量证据还表明，葡萄糖与 ABI 和 BTX 相比，疗效差异可能微乎其微。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cranio-The Journal of Craniomandibular & Sleep Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.50

自引率

12.50%

发文量

审稿时长

>12 weeks

期刊介绍： CRANIO: The Journal of Craniomandibular & Sleep Practice is the oldest and largest journal in the world devoted to temporomandibular disorders, and now also includes articles on all aspects of sleep medicine. The Journal is multidisciplinary in its scope, with editorial board members from all areas of medicine and dentistry, including general dentists, oral surgeons, orthopaedists, radiologists, chiropractors, professors and behavioural scientists, physical therapists, acupuncturists, osteopathic and ear, nose and throat physicians. CRANIO publishes commendable works from outstanding researchers and clinicians in their respective fields. The multidisciplinary format allows individuals practicing with a TMD emphasis to stay abreast of related disciplines, as each issue presents multiple topics from overlapping areas of interest. CRANIO''s current readership (thousands) is comprised primarily of dentists; however, many physicians, physical therapists, chiropractors, osteopathic physicians and other related specialists subscribe and contribute to the Journal.