{"title":"A cross-species foundation model for single cells","authors":"Korbinian Traeuble, Matthias Heinig","doi":"10.1038/s41422-024-01045-9","DOIUrl":null,"url":null,"abstract":"<p><b>Foundation models in transcriptomics have gained attention due to their ability to generalize across tasks with limited labeled data. GeneCompass builds upon these models by incorporating prior biological knowledge and datasets from both human and mouse cells, enhancing its capacity for cross-species analysis and advancing the field of single-cell transcriptomics.</b></p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":null,"pages":null},"PeriodicalIF":28.1000,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41422-024-01045-9","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Foundation models in transcriptomics have gained attention due to their ability to generalize across tasks with limited labeled data. GeneCompass builds upon these models by incorporating prior biological knowledge and datasets from both human and mouse cells, enhancing its capacity for cross-species analysis and advancing the field of single-cell transcriptomics.
期刊介绍：
Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.
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