Progress in Transdifferentiation of Autologous Alternative Cell Sources into Corneal Epithelial Cells.

IF 4.5 3区医学 Q2 CELL & TISSUE ENGINEERING Stem Cell Reviews and Reports Pub Date : 2024-10-31 DOI:10.1007/s12015-024-10808-1

Bei Wang, Jiang-Lan Zhao, Wan-Ying Cai, Gong-Yue Wang, Yu-Zhi Li, Jia-Song Wang, Hua-Tao Xie, Ming-Chang Zhang

引用次数: 0

Abstract

Corneal limbal epithelial stem cells (LESCs) play a crucial role in corneal epithelium regeneration. Severe damage to these cells can result in limbal stem cell deficiency (LSCD), characterized by repeated corneal conjunctivalization, leading to corneal turbidity and scar formation. Restoring functional LESCs and their ecological location are essential for treating LSCD. The goal of this review is to provide researchers and clinicians with key insights into LESCs biology and to conclude the current cell-based therapies advancement in LSCD treatments. Therapeutic cell resources mainly include mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), skin keratinocyte stem cells (SKCs), and oral mucosal epithelial cells (OMECs).

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自体替代细胞源转分化为角膜上皮细胞的研究进展。

角膜缘上皮干细胞（LESCs）在角膜上皮再生中起着至关重要的作用。这些细胞的严重损伤可导致角膜缘干细胞缺乏症（LSCD），其特征是反复角膜结膜化，导致角膜浑浊和疤痕形成。恢复功能性LESCs及其生态位置对治疗LSCD至关重要。本综述旨在为研究人员和临床医生提供有关 LESCs 生物学的重要见解，并总结目前基于细胞的疗法在治疗 LSCD 方面的进展。治疗细胞资源主要包括间充质干细胞（MSCs）、胚胎干细胞（ESCs）、诱导多能干细胞（iPSCs）、皮肤角质细胞干细胞（SKCs）和口腔粘膜上皮细胞（OMECs）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem Cell Reviews and Reports 医学-细胞生物学

CiteScore

9.30

自引率

4.20%

发文量

审稿时长

3 months

期刊介绍： The purpose of Stem Cell Reviews and Reports is to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal will consider for publication: i) solicited or unsolicited reviews of topical areas of stem cell biology that highlight, critique and synthesize recent important findings in the field. ii) full length and short reports presenting original experimental work. iii) translational stem cell studies describing results of clinical trials using stem cells as therapeutics. iv) papers focused on diseases of stem cells. v) hypothesis and commentary articles as opinion-based pieces in which authors can propose a new theory, interpretation of a controversial area in stem cell biology, or a stem cell biology question or paradigm. These articles contain more speculation than reviews, but they should be based on solid rationale. vi) protocols as peer-reviewed procedures that provide step-by-step descriptions, outlined in sufficient detail, so that both experts and novices can apply them to their own research. vii) letters to the editor and correspondence. In order to facilitate this exchange of scientific information and exciting novel ideas, the journal has created five thematic sections, focusing on: i) the role of adult stem cells in tissue regeneration; ii) progress in research on induced pluripotent stem cells, embryonic stem cells and mechanism governing embryogenesis and tissue development; iii) the role of microenvironment and extracellular microvesicles in directing the fate of stem cells; iv) mechanisms of stem cell trafficking, stem cell mobilization and homing with special emphasis on hematopoiesis; v) the role of stem cells in aging processes and cancerogenesis.