Decoding secret role of mesenchymal stem cells in regulating cancer stem cells and drug resistance

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-01 DOI:10.1016/j.bbcan.2024.189205
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Abstract

Drug resistance caused by the efflux of chemotherapeutic drugs is one of the most challenging obstacles to successful cancer therapy. Several efflux transporters have been identified since the discovery of the P-gp/ABCB1 transporter in 1976. Over the last four decades, researchers have focused on developing efflux transporter inhibitors to overcome drug resistance. However, even with the third-generation inhibitors available, we are still far from effectively inhibiting the efflux transporters. Additionally, Cancer stem cells (CSCs) pose another significant challenge, contributing to cancer recurrence even after successful treatment. The ability of CSCs to enter dormancy and evade detection makes them almost invulnerable to chemotherapeutic drug treatment. In this review, we discuss how Mesenchymal stem cells (MSCs), one of the key components of the Tumor Microenvironment (TME), regulate both the CSCs and efflux transporters. We propose a new approach focusing on MSCs, which can be crucial to successfully address CSCs and efflux transporters.
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解密间充质干细胞在调节癌症干细胞和耐药性方面的秘密作用。
化疗药物外流导致的耐药性是成功治疗癌症的最大障碍之一。自 1976 年发现 P-gp/ABCB1 转运体以来,已经发现了多种外流转运体。过去四十年来,研究人员一直致力于开发外排转运体抑制剂,以克服耐药性。然而,即使有了第三代抑制剂,我们仍远不能有效抑制外排转运体。此外,癌症干细胞(CSCs)构成了另一个重大挑战,即使在成功治疗后也会导致癌症复发。癌干细胞能够进入休眠状态并逃避检测,这使得它们几乎不受化疗药物治疗的影响。在这篇综述中,我们将讨论间充质干细胞(MSCs)作为肿瘤微环境(TME)的关键组成部分之一,是如何调控CSCs和外排转运体的。我们提出了一种以间叶干细胞为重点的新方法,这对成功解决干细胞和外排转运体问题至关重要。
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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
期刊最新文献
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