Retina in Clinical High-Risk and First-Episode Psychosis.

IF 5.3 1区医学 Q1 PSYCHIATRY Schizophrenia Bulletin Pub Date : 2024-11-02 DOI:10.1093/schbul/sbae189

Cemal Demirlek, Berat Arslan, Merve S Eyuboglu, Berna Yalincetin, Ferdane Atas, Ezgi Cesim, Muhammed Demir, Simge Uzman Ozbek, Elif Kizilay, Burcu Verim, Ekin Sut, Burak Baykara, Mahmut Kaya, Berna B Akdede, Emre Bora

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Abstract

Background and hypothesis: Abnormalities in the retina are observed in psychotic disorders, especially in schizophrenia.

Study design: Using spectral-domain optical coherence tomography, we investigated structural retinal changes in relatively metabolic risk-free youth with clinical high-risk (CHR, n = 34) and first-episode psychosis (FEP, n = 30) compared with healthy controls (HCs, n = 28).

Study results: Total retinal macular thickness/volume of the right eye increased in FEP (effect sizes, Cohen's d = 0.69/0.66) and CHR (d = 0.67/0.76) compared with HCs. Total retinal thickness/volume was not significantly different between FEP and CHR. Macular retinal nerve fiber layer (RNFL) thickness/volume of the left eye decreased in FEP compared with HCs (d = -0.75/-0.66). Peripapillary RNFL thickness was not different between groups. The ganglion cell (GCL), inner plexiform (IPL), and inner nuclear (INL) layers thicknesses/volumes of both eyes increased in FEP compared with HCs (d = 0.70-1.03). GCL volumes of both eyes, IPL thickness/volume of the left eye, and INL thickness/volume of both eyes increased in CHR compared with HCs (d = 0.64-1.01). In the macula, while central sector thickness/volume decreased (d = -0.62 to -0.72), superior outer (peri-foveal) sector thickness/volume of both eyes increased (d = 0.81 to 0.86) in FEP compared with HCs.

Conclusions: The current findings suggest that distinct regions and layers of the retina may be differentially impacted during the emergence and early phase of psychosis. Consequently, oculomics could play significant roles, not only as a diagnostic tool but also as a mirror reflecting neurobiological changes at axonal and cellular levels.

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临床高危和首发精神病患者的视网膜。

背景与假设：研究设计：研究设计：我们使用光谱域光学相干断层扫描技术，调查了相对无代谢风险的临床高危（CHR，n = 34）和首发精神病（FEP，n = 30）青少年与健康对照组（HCs，n = 28）的视网膜结构变化：研究结果：与健康对照组相比，FEP（效应大小，Cohen's d = 0.69/0.66）和CHR（d = 0.67/0.76）患者右眼视网膜黄斑总厚度/体积增加。FEP 和 CHR 的视网膜总厚度/体积无明显差异。与 HCs（d = -0.75/-0.66）相比，FEP 左眼的黄斑视网膜神经纤维层（RNFL）厚度/体积有所下降。组间毛周 RNFL 厚度无差异。与 HCs 相比，FEP 患者双眼的神经节细胞层 (GCL)、内丛状层 (IPL) 和核内层 (INL) 厚度/体积均有所增加（d = 0.70-1.03）。与 HC 相比，CHR 双眼的 GCL 体积、左眼的 IPL 厚度/体积和 INL 厚度/体积均有所增加（d = 0.64-1.01）。在黄斑部，与 HCs 相比，FEP 的中央区厚度/体积减少（d = -0.62 至 -0.72），但双眼的外上（眼窝周围）区厚度/体积增加（d = 0.81 至 0.86）：目前的研究结果表明，视网膜的不同区域和视网膜层在精神病的出现和早期阶段可能会受到不同程度的影响。因此，视觉组学不仅可以作为诊断工具，还可以作为反映轴突和细胞水平神经生物学变化的一面镜子，发挥重要作用。

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来源期刊

Schizophrenia Bulletin 医学-精神病学

CiteScore

11.40

自引率

6.10%

发文量

163

审稿时长

4-8 weeks

期刊介绍： Schizophrenia Bulletin seeks to review recent developments and empirically based hypotheses regarding the etiology and treatment of schizophrenia. We view the field as broad and deep, and will publish new knowledge ranging from the molecular basis to social and cultural factors. We will give new emphasis to translational reports which simultaneously highlight basic neurobiological mechanisms and clinical manifestations. Some of the Bulletin content is invited as special features or manuscripts organized as a theme by special guest editors. Most pages of the Bulletin are devoted to unsolicited manuscripts of high quality that report original data or where we can provide a special venue for a major study or workshop report. Supplement issues are sometimes provided for manuscripts reporting from a recent conference.