Clinicopathological analysis of hybrid carcinomas of the salivary glands: A systematic review.

IF 2.2 3区医学 Q2 Dentistry Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-10-31 DOI:10.1016/j.jormas.2024.102132

Talita de Carvalho Kimura, Reydson Alcides de Lima-Souza, Luccas Lavareze, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano

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Abstract

Hybrid carcinomas (HC) are the association of two or more malignant neoplasms arising within the same topographical area. The present study is a systematic review of HC of the salivary glands. This study aimed to assess HC clinicopathological features and molecular profile. Observational studies, case series, and case reports were included. PubMed, Scopus, EMBASE, Lilacs, Web of Science, and gray literature were searched until June 2024. A total of 18 articles including 34 patients were included. HC of the salivary glands is presented as a painless mass affecting mainly the parotid gland of adults with a preference for male patients. Histologically, adenoid cystic carcinoma and epithelial-myoepithelial carcinoma were the most prevalent association, being surgical excision with radiotherapy the most common treatment. The most aggressive component, even when representing only a small proportion of the tumor, should guide the patient's treatment. Further molecular studies are necessary to determine if HC are distinct entities or biologically identical to the individual neoplasms. In conclusion, this systematic review may contribute to a better understanding of this rare lesion, their biological behavior, treatments employed, and the outcome of these patients.

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唾液腺混合癌的临床病理分析：系统综述。

混合癌（HC）是指在同一地形区域内出现的两种或两种以上恶性肿瘤。本研究对唾液腺混合癌进行了系统回顾。本研究旨在评估唾液腺肿瘤的临床病理特征和分子特征。研究纳入了观察性研究、系列病例和病例报告。研究人员检索了 PubMed、Scopus、EMBASE、Lilacs、Web of Science 和灰色文献，检索期至 2024 年 6 月。共纳入 18 篇文章，包括 34 名患者。唾液腺 HC 主要表现为影响成人腮腺的无痛性肿块，好发于男性患者。从组织学角度看，腺样囊性癌和上皮-肌上皮癌是最常见的癌种，手术切除和放射治疗是最常见的治疗方法。由此可见，最具侵袭性的成分可能会指导患者的治疗和预后。有必要进行进一步的分子研究，以确定 HC 是不同的实体，还是在生物学上与单个肿瘤相同。总之，本系统综述有助于更好地了解这种罕见病变、其生物学行为、采用的治疗方法以及这些患者的预后。

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来源期刊

Journal of Stomatology Oral and Maxillofacial Surgery Dentistry-Oral Surgery

CiteScore

2.20

自引率

9.10%

发文量

305

期刊介绍： J Stomatol Oral Maxillofac Surg publishes research papers and techniques - (guest) editorials, original articles, reviews, technical notes, case reports, images, letters to the editor, guidelines - dedicated to enhancing surgical expertise in all fields relevant to oral and maxillofacial surgery: from plastic and reconstructive surgery of the face, oral surgery and medicine, … to dentofacial and maxillofacial orthopedics. Original articles include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey Platforms.