{"title":"Potential circadian rhythms impacts on amblyopia treatment outcomes","authors":"Saeed Aljohani","doi":"10.1016/j.mehy.2024.111514","DOIUrl":null,"url":null,"abstract":"<div><div>Traditional treatments for amblyopia, such as patching and atropine penalization, often yield variable outcomes, underscoring the need for alternative or supplementary strategies. Circadian rhythms, which regulate various physiological processes including those associated with ocular health, may significantly influence the success of these treatments. The report proposes three hypotheses: (1) aligning amblyopia treatments with circadian rhythms through the modulation of melatonin and dopamine levels may enhance treatment responsiveness, (2) synchronizing treatment schedules with the patient’s diurnal rhythms could improve effectiveness, and (3) disruptions in circadian rhythms might negatively affect treatment outcomes. The expected implications of these hypotheses suggest a need for further research into the interplay between circadian rhythms and amblyopia therapy to optimize outcomes.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"193 ","pages":"Article 111514"},"PeriodicalIF":2.1000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical hypotheses","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306987724002573","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Traditional treatments for amblyopia, such as patching and atropine penalization, often yield variable outcomes, underscoring the need for alternative or supplementary strategies. Circadian rhythms, which regulate various physiological processes including those associated with ocular health, may significantly influence the success of these treatments. The report proposes three hypotheses: (1) aligning amblyopia treatments with circadian rhythms through the modulation of melatonin and dopamine levels may enhance treatment responsiveness, (2) synchronizing treatment schedules with the patient’s diurnal rhythms could improve effectiveness, and (3) disruptions in circadian rhythms might negatively affect treatment outcomes. The expected implications of these hypotheses suggest a need for further research into the interplay between circadian rhythms and amblyopia therapy to optimize outcomes.
期刊介绍：
Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.
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