Alcohol’s necessary accessory

IF 21.2 1区医学 Q1 NEUROSCIENCES Nature neuroscience Pub Date : 2024-11-04 DOI:10.1038/s41593-024-01802-4

Shari Wiseman

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酒精的必需品

酒精对大脑的影响部分是通过它作为 GABAA 受体（GABAARs）的正性异位调节剂（PAM）来介导的，但连接 GABAARs 和酒精相关行为的分子机制仍不清楚。为了解决这个问题，Wang 等人首先使用蛋白质组学方法研究了酒精使用障碍（AUD）患者和对照组供体海马样本中质膜蛋白的不同水平。这一筛选发现，在 AUD 患者中，TMEM132B（一种功能不明的跨膜蛋白）的水平降低了。作者接着证明，TMEM132B 可与多个 GABAAR 亚基结合，定位于抑制性突触，促进 GABAAR 表面表达，并减缓受体失活。酒精作为 GABAAR PAM 也需要 TMEM132B。最后，Tmem132b基因敲除小鼠表现出的酒精抗焦虑和镇静催眠作用减弱，狂饮现象增加。这些发现揭示了抑制性神经递质的基本生物学特性以及可能导致AUD的机制：细胞 https://doi.org/10.1016/j.cell.2024.09.006 (2024)

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.

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