Revolutionizing medicine: Recent developments and future prospects in stem-cell therapy.

IF 12.5 2区 医学 Q1 SURGERY International journal of surgery Pub Date : 2024-11-05 DOI:10.1097/JS9.0000000000002109
Bashdar Mahmud Hussen, Mohammad Taheri, Raya Kh Yashooa, Gaylany H Abdullah, Snur Rasool Abdullah, Ramiar Kamal Kheder, Suhad A Mustafa
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Abstract

Stem-cell therapy is a revolutionary frontier in modern medicine, offering enormous capacity to transform the treatment landscape of numerous debilitating illnesses and injuries. This review examines the revolutionary frontier of treatments utilizing stem cells, highlighting the distinctive abilities of stem cells to undergo regeneration and specialized cell differentiation into a wide variety of phenotypes. This paper aims to guide researchers, physicians, and stakeholders through the intricate terrain of stem-cell therapy, examining the processes, applications, and challenges inherent in utilizing stem cells across diverse medical disciplines. The historical journey from foundational contributions in the late 19th and early 20th centuries to recent breakthroughs, including ESC isolation and iPSC discovery, has set the stage for monumental leaps in medical science. Stem cells' regenerative potential spans embryonic, adult, induced pluripotent, and perinatal stages, offering unprecedented therapeutic opportunities in cancer, neurodegenerative disorders, cardiovascular ailments, spinal cord injuries, diabetes, and tissue damage. However, difficulties, such as immunological rejection, tumorigenesis, and precise manipulation of stem-cell behavior, necessitate comprehensive exploration and innovative solutions. This manuscript summarizes recent biotechnological advancements, critical trial evaluations, and emerging technologies, providing a nuanced understanding of the triumphs, difficulties, and future trajectories in stem cell-based regenerative medicine. Future directions, including precision medicine integration, immune modulation strategies, advancements in gene-editing technologies, and bioengineering synergy, offer a roadmap in stem cell treatment. The focus on stem-cell therapy's potential highlights its significant influence on contemporary medicine and points to a future in which individualized regenerative therapies will alleviate various medical disorders.

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医学革命:干细胞疗法的最新发展和未来前景。
干细胞疗法是现代医学的一个革命性前沿领域,具有改变众多衰弱疾病和损伤治疗格局的巨大能力。这篇综述探讨了利用干细胞进行治疗的革命性前沿,强调了干细胞再生和特化细胞分化成各种表型的独特能力。本文旨在引导研究人员、医生和利益相关者了解干细胞疗法的复杂地形,研究不同医学学科利用干细胞的过程、应用和固有挑战。从19世纪末20世纪初的奠基性贡献到最近的突破性进展,包括干细胞分离和iPSC的发现,这些历史进程为医学科学的巨大飞跃奠定了基础。干细胞的再生潜力横跨胚胎、成人、诱导多能和围产期阶段,为癌症、神经退行性疾病、心血管疾病、脊髓损伤、糖尿病和组织损伤提供了前所未有的治疗机会。然而,由于存在免疫排斥、肿瘤发生和干细胞行为精确控制等困难,有必要进行全面探索,并提出创新解决方案。本手稿总结了最近的生物技术进步、关键试验评估和新兴技术,提供了对基于干细胞的再生医学的胜利、困难和未来轨迹的细微理解。未来的发展方向,包括精准医学整合、免疫调节策略、基因编辑技术的进步以及生物工程的协同作用,为干细胞治疗提供了路线图。对干细胞疗法潜力的关注凸显了其对当代医学的重大影响,并预示着个体化再生疗法将缓解各种疾病的未来。
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来源期刊
CiteScore
17.70
自引率
3.30%
发文量
0
审稿时长
6-12 weeks
期刊介绍: The International Journal of Surgery (IJS) has a broad scope, encompassing all surgical specialties. Its primary objective is to facilitate the exchange of crucial ideas and lines of thought between and across these specialties.By doing so, the journal aims to counter the growing trend of increasing sub-specialization, which can result in "tunnel-vision" and the isolation of significant surgical advancements within specific specialties.
期刊最新文献
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