Exploring paraptosis as a therapeutic approach in cancer treatment.

IF 9 2区 医学 Q1 CELL BIOLOGY Journal of Biomedical Science Pub Date : 2024-11-04 DOI:10.1186/s12929-024-01089-4
Ling-Chu Chang, Shih-Kai Chiang, Shuen-Ei Chen, Mien-Chie Hung
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Abstract

A variety of cell death pathways play critical roles in the onset and progression of multiple diseases. Paraptosis, a unique form of programmed cell death, has gained significant attention in recent years. Unlike apoptosis and necrosis, paraptosis is characterized by cytoplasmic vacuolization, swelling of the endoplasmic reticulum and mitochondria, and the absence of caspase activation. Numerous natural products, synthetic compounds, and newly launched nanomedicines have been demonstrated to prime cell death through the paraptotic program and may offer novel therapeutic strategies for cancer treatment. This review summarizes recent findings, delineates the intricate network of signaling pathways underlying paraptosis, and discusses the potential therapeutic implications of targeting paraptosis in cancer treatment. The aim of this review is to expand our understanding of this unique cell death process and explore the potential therapeutic implications of targeting paraptosis in cancer treatment.

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探索将副aptosis作为癌症治疗方法。
多种细胞死亡途径在多种疾病的发生和发展中起着至关重要的作用。副凋亡是一种独特的程序性细胞死亡形式,近年来受到了广泛关注。与细胞凋亡和坏死不同,副凋亡的特点是细胞质空泡化、内质网和线粒体肿胀以及没有卡巴酶激活。大量天然产品、合成化合物和新推出的纳米药物已被证实可通过凋亡期程序促进细胞死亡,并可为癌症治疗提供新的治疗策略。本综述总结了最近的研究发现,勾勒出了支撑副aptosis的错综复杂的信号通路网络,并讨论了在癌症治疗中靶向副aptosis的潜在治疗意义。本综述旨在扩大我们对这一独特细胞死亡过程的了解,并探讨在癌症治疗中靶向凋亡的潜在治疗意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Biomedical Science
Journal of Biomedical Science 医学-医学:研究与实验
CiteScore
18.50
自引率
0.90%
发文量
95
审稿时长
1 months
期刊介绍: The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.
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