Acupoint catgut embedding regulates community structure of intestinal flora in central obesity during perimenopause.

IF 1.2 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Women & Health Pub Date : 2024-11-01 Epub Date: 2024-11-04 DOI:10.1080/03630242.2024.2422876
Yuanyuan Jin, Yifan Huang, Jianfang Zhu, Dan Liao, Shumei Zeng, Xiaoqing Jin
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Abstract

Acupoint catgut embedding (ACE) is a safe and effective method for treating obesity. However, how it modulates intestinal flora and adiponectin remains unclear. We employed 16s rRNA sequencing technology to investigate ACE induced changes in intestinal flora and its association with adiponectin in subjects who received real (n = 41) and Sham (n = 41) stimulation. After treatment, the ACE group's body weight, BMI, WC, HC, WHtR, and WHR were significantly lower than those of the Control group (p < .01), there was statistically significant differences in ADPN between the two groups (p < .01). ACE reduces the species abundance and increased the diversity and differences of the gut microbiota in perimenopausal patients with central obesity. Most notably, there was an increase in Kosakonia and Klebsiella after ACE treatment in the patients. Significant negatively correlations were found between body weight/waist circumference and adiponectin. Increases in Klebsiella and Kosakonia were positively correlated with adiponectin, and were negatively correlated with body weight/waist circumference. Our results showed increases in Klebsiella and Kosakonia were correlated with body weight/waist circumference and adiponectin. These findings suggest that ACE-induced weight loss is probably in part associated with increases in adiponectin, Klebsiella and Kosakonia.Trial re-registration: www.chictr.org.cn, ID: ChiCTR2400087718, Registration Date: August 2nd 2024.

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穴位猫肠埋线可调节围绝经期中心性肥胖症患者肠道菌群的群落结构。
穴位猫肠埋(ACE)是治疗肥胖症的一种安全有效的方法。然而,它如何调节肠道菌群和脂肪连蛋白仍不清楚。我们采用 16s rRNA 测序技术,研究了 ACE 引起的肠道菌群变化及其与接受真实刺激(41 人)和虚假刺激(41 人)的受试者体内脂肪连素的关系。治疗后,ACE 组的体重、BMI、WC、HC、WHtR 和 WHR 显著低于对照组(P P 试验重新注册:www.chictr.org.cn,ID:ChiCTR2400087718,注册日期:2024 年 8 月 2 日:2024 年 8 月 2 日。
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来源期刊
Women & Health
Women & Health Multiple-
CiteScore
2.70
自引率
0.00%
发文量
73
期刊介绍: Women & Health publishes original papers and critical reviews containing highly useful information for researchers, policy planners, and all providers of health care for women. These papers cover findings from studies concerning health and illness and physical and psychological well-being of women, as well as the environmental, lifestyle and sociocultural factors that are associated with health and disease, which have implications for prevention, early detection and treatment, limitation of disability and rehabilitation.
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