Research trends and hotspots of radioiodine-refractory thyroid cancer treatment in the twenty-first century: a bibliometric analysis.

IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Annals of Nuclear Medicine Pub Date : 2024-11-05 DOI:10.1007/s12149-024-01998-2
Yuhang Xue, Yuzhe Zhang, Xintao Ding, Xinyu Wu, Bo Li, Ye Zhang, Yongju Gao
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Abstract

The treatment of radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) has made significant advancements in the twenty-first century. This study aimed to assess the current state of research and identify potential new directions by conducting a bibliometric analysis of scientific publications on RAIR-DTC treatment. Publications relevant to RAIR-DTC, published from January 1, 2000, to December 31, 2023, were retrieved from the Web of Science Core Collection. Bibliometric analyses of major keywords, authors, countries, institutions, publications, and journals were conducted using CiteSpace and VOSviewer. A total of 859 papers were included in the analysis. The results demonstrated a rising trend in the number of publications over time. The United States was identified as the leading contributor in terms of publication output, citations, and international collaborations. Gustave Roussy emerged as the top organization in publication productivity, while the journal Thyroid had the highest number of related publications. The research on RAIR treatment was categorized into three key hotspots: clinical trials of targeted therapies, novel therapeutic strategies, and debates surrounding the RAIR-DTC management. RAIR-DTC research is expanding from the clinical trial phase of tyrosine kinase inhibitor monotherapy to a more complex combination therapy strategy, in particular, the synergistic effect of immune checkpoint inhibitors and other therapeutic agents, requiring more high-quality prospective studies to validate the clinical benefits. Moreover, the timely identification of RAIR-DTC patients holds the potential to enable early disease intervention, constituting a pivotal novel research direction in the future.

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21世纪放射性碘难治性甲状腺癌治疗的研究趋势和热点:文献计量分析。
放射性碘难治性分化型甲状腺癌(RAIR-DTC)的治疗在二十一世纪取得了重大进展。本研究旨在通过对有关 RAIR-DTC 治疗的科学出版物进行文献计量分析,评估研究现状并确定潜在的新方向。研究人员从科学网核心数据库中检索了 2000 年 1 月 1 日至 2023 年 12 月 31 日期间发表的与 RAIR-DTC 相关的出版物。使用 CiteSpace 和 VOSviewer 对主要关键词、作者、国家、机构、出版物和期刊进行了文献计量分析。共有 859 篇论文被纳入分析。结果表明,随着时间的推移,论文数量呈上升趋势。美国被确定为在出版物产出、引用和国际合作方面的主要贡献者。古斯塔夫-鲁西(Gustave Roussy)是发表论文数量最多的机构,而《甲状腺》杂志的相关论文数量最多。RAIR治疗研究分为三大热点:靶向疗法的临床试验、新型治疗策略以及围绕RAIR-DTC管理的争论。RAIR-DTC研究正从酪氨酸激酶抑制剂单药治疗的临床试验阶段向更复杂的联合治疗策略扩展,尤其是免疫检查点抑制剂和其他治疗药物的协同作用,需要更多高质量的前瞻性研究来验证其临床获益。此外,及时发现 RAIR-DTC 患者有可能实现早期疾病干预,这也是未来一个重要的新研究方向。
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来源期刊
Annals of Nuclear Medicine
Annals of Nuclear Medicine 医学-核医学
CiteScore
4.90
自引率
7.70%
发文量
111
审稿时长
4-8 weeks
期刊介绍: Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
期刊最新文献
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