Desidustat: a novel PHD inhibitor for the treatment of CKD-induced anemia.

Frontiers in nephrology Pub Date : 2024-10-22 eCollection Date: 2024-01-01 DOI:10.3389/fneph.2024.1459425
Amit Joharapurkar, Vrajesh Pandya, Harilal Patel, Mukul Jain, Ranjit Desai
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Abstract

Desidustat is a small molecule inhibitor of hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) discovered and developed by Zydus Lifesciences for the treatment of anemia associated with chronic kidney disease (CKD). This review summarizes the preclinical and clinical profile of desidustat which led to its approval and clinical use in India.

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Desidustat:治疗慢性肾功能衰竭所致贫血的新型 PHD 抑制剂。
Desidustat 是一种低氧诱导因子-脯氨酰羟化酶 (HIF-PH) 小分子抑制剂,由 Zydus Lifesciences 发现并开发,用于治疗与慢性肾病 (CKD) 相关的贫血。本综述概述了地司他的临床前和临床概况,地司他在印度获得批准并投入临床使用。
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