HIV-1 remission following stem cell transplant without CCR5Δ32 mutation

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Abstract

We report the first case of a person achieving sustained HIV-1 remission after transplantation with allogeneic hematopoietic stem cells that express wild-type CCR5 and thus are permissive to HIV-1 infection. The 53-year-old man received the transplant in 2018 to treat a rare myeloid sarcoma and has not experienced viral rebound since discontinuing antiretroviral therapy in November 2021.

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干细胞移植后艾滋病毒-1缓解,但无CCR5Δ32突变
我们报告了首例移植了表达野生型CCR5从而允许HIV-1感染的异体造血干细胞后实现HIV-1持续缓解的病例。这名 53 岁的男子于 2018 年接受了移植,以治疗罕见的骨髓肉瘤,自 2021 年 11 月停止抗逆转录病毒疗法以来,他的病毒没有反弹。
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