Autologous platelet-rich fibrin enhances skin wound healing in a feline trauma model.

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES BMC Veterinary Research Pub Date : 2024-11-06 DOI:10.1186/s12917-024-04358-4
Shuai Zhang, Haoyang Tan, Xin Cheng, Xinyi Dou, Hao Fang, Cuihong Zhang, Guiyan Yang, Haotian Yang, Yuan Zhao, Tongtong Feng, Honggang Fan, Wanli Sha
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Abstract

Trauma is a common cause of cutaneous surgical disease with an increased risk of secondary infection in cat clinics. Platelet-rich fibrin (PRF), a platelet and leukocyte concentrate containing multiple cytokines and growth factors, is known to accelerate the healing of wounds. However, how PRF affects wound healing in the cat trauma model has not been fully investigated. The study aimed to examine the impact of PRF on skin wound healing in the cat trauma model. In this study, PRF from cats was successfully produced for our investigation. The models of feline trauma were effectively established. A total of 18 cats were randomly divided into 3 groups (n = 6): (1) Control group (CON); (2) PRF group; (3) Manuka honey group (MAN, as a positive control). Experiments were performed separately on days 7, 14, 21, and 28. Our results showed that PRF was a safe and efficient method of wound healing that did not influence the cat's body temperature, respiration rate, and heart rate (HR). PRF accelerated skin wound healing in the cat trauma model based on the rate and histological observation of wound healing. In addition, PRF promoted the production of growth factors and suppressed inflammation during wound healing. PRF accelerated wound healing by increasing the formation of collagen fibers, as shown by Masson-trichrome staining. The outcomes of the PRF and MAN groups were comparable. In conclusion, PRF improves the healing of skin wounds in cats by boosting the synthesis of growth factors, reducing inflammation, and enhancing the synthesis of collagen fibers.

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自体富血小板纤维蛋白可促进猫科动物创伤模型的皮肤伤口愈合。
外伤是皮肤外科疾病的常见原因,在猫科动物诊所中,外伤会增加继发感染的风险。富血小板纤维蛋白(PRF)是一种血小板和白细胞浓缩物,含有多种细胞因子和生长因子,可加速伤口愈合。然而,PRF 如何影响猫创伤模型的伤口愈合尚未得到充分研究。本研究旨在探讨 PRF 对猫创伤模型中皮肤伤口愈合的影响。在本研究中,我们成功制作了猫的 PRF 用于研究。有效建立了猫创伤模型。总共 18 只猫被随机分为 3 组(n = 6):(1)对照组(CON);(2)PRF 组;(3)麦卢卡蜂蜜组(MAN,作为阳性对照)。实验分别在第 7、14、21 和 28 天进行。结果表明,PRF 是一种安全有效的伤口愈合方法,不会影响猫的体温、呼吸频率和心率(HR)。根据伤口愈合的速度和组织学观察,PRF 加快了猫创伤模型的皮肤伤口愈合。此外,PRF 还能促进伤口愈合过程中生长因子的产生并抑制炎症。Masson-trichrome 染色法显示,PRF 通过增加胶原纤维的形成加速了伤口愈合。PRF 组和 MAN 组的疗效相当。总之,PRF 通过促进生长因子的合成、减少炎症和增强胶原纤维的合成,改善了猫皮肤伤口的愈合。
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来源期刊
BMC Veterinary Research
BMC Veterinary Research VETERINARY SCIENCES-
CiteScore
4.80
自引率
3.80%
发文量
420
审稿时长
3-6 weeks
期刊介绍: BMC Veterinary Research is an open access, peer-reviewed journal that considers articles on all aspects of veterinary science and medicine, including the epidemiology, diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.
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