Impaired Glucose Homeostasis Accompanies Cellular Changes in Endocrine Pancreas after Atorvastatin Administration.

Q3 Medicine Journal of Microscopy and Ultrastructure Pub Date : 2024-06-20 eCollection Date: 2024-07-01 DOI:10.4103/jmau.jmau_41_21

Ahmed A M Abdel-Hamid, Alaa El-Din L Firgany

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Abstract

Atorvastatin (ATOR) has been reported to increase the risk for diabetes mellitus. Therefore, in the current study, we focused on studying the effect of ATOR on the structure of islets of Langerhans including their various cellular components as well as on glucose homeostasis. We detected a statistically significant increase (P < 0.05) in β-cell mass and percentage with a significant decrease in α-cell area and percentage in animals that received ATOR compared to control ones. In addition, a statistically significant increase (P < 0.05) in the β-cell proliferation was observed in the ATOR group with negligible change in expression of inflammatory cytokines of the islets. A significant downregulation in apoptosis alongside a significant upregulation in anti-apoptosis were detected in islets of animals treated with ATOR. Moreover, there was a significant impairment in various parameters of glucose homeostasis in the ATOR-treated group. Therefore, ATOR may induce insulin resistance-like state that was demarcated at cellular as well as at biochemical levels with little or no inflammatory response.

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服用阿托伐他汀后内分泌胰腺细胞变化伴随着葡萄糖稳态受损

据报道，阿托伐他汀（ATOR）会增加罹患糖尿病的风险。因此，在本研究中，我们重点研究了 ATOR 对朗格汉斯胰岛结构（包括其各种细胞成分）以及葡萄糖稳态的影响。我们发现，与对照组相比，接受 ATOR 治疗的动物的 β 细胞质量和百分比显著增加（P < 0.05），而 α 细胞面积和百分比显著减少。此外，在 ATOR 组中观察到 β 细胞增殖有统计学意义的显著增加（P < 0.05），而胰岛炎症细胞因子的表达几乎没有变化。接受 ATOR 治疗的动物的胰岛细胞凋亡明显减少，而抗凋亡明显增加。此外，ATOR 治疗组的各种糖稳态参数也明显受损。因此，ATOR 可能会诱发胰岛素抵抗样状态，这种状态在细胞和生化水平上都有明显的特征，但几乎没有炎症反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Microscopy and Ultrastructure Medicine-Nephrology

CiteScore

1.90

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0.00%

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