Junzhi Pan , Huayuan Liu , Junpeng Xu , Xiaofeng Xu , Yu Qi , Chaojie Wang , Changle Wu , Zhongmin Sun , Yali Lv , Pengcheng Yan
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引用次数: 0
Abstract
Five previously undescribed chromane-type meroditerpenoids, sargasilols J–N (1–5), were isolated from an EtOAc-soluble extract of the brown alga Sargassum siliquastrum collected in the China Sea. The chemical structures of these meroditerpenoids were determined by extensive spectroscopic analyses, including 1D/2D NMR, ECD, and HR-ESI-MS data. Compound 3 exhibited potent anti-neuroinflammatory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglia cells, with an IC50 value of 9.9 μM.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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