{"title":"Osteosclerosing multiple myeloma: A case highlighting critical value of image findings for the diagnosis","authors":"Yuko Kobashi , Hideaki Suzuki , Masaru Nakagawa , Toshio Kojima , Ryusuke Tsujimura , Katsuhiro Miura , Hideki Nakamura , Masahiro Okada","doi":"10.1016/j.radcr.2024.10.059","DOIUrl":null,"url":null,"abstract":"<div><div>Osteosclerosing myeloma is a specific form of multiple myeloma. We present a case of a 63-year-old woman who was found to have anemia during her medical checkup. Her blood tests suggested multiple myeloma, but she had diffuse osteosclerotic changes mainly in the axial skeleton, such as osteoblastic bone metastasis. On the other hand, the bone scintigraphy and FDG-PET showed almost normal. Osteosclerosing myeloma is similar to osteoblastic bone metastases and POEMS (<em>p</em>olyneuropathy, <em>o</em>rganomegaly, <em>e</em>ndocrinopathy, <em>m</em>onoclonal gammopathy, and <em>s</em>kin changes) syndrome, but is characterized by a lack of response to nuclear medicine testing, reflecting very low activity. This case highlights the critical value of the image findings of osteosclerosis myeloma and promotes awareness of this highly unusual but unique form of the disease.</div></div>","PeriodicalId":53472,"journal":{"name":"Radiology Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1930043324011695","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
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Abstract
Osteosclerosing myeloma is a specific form of multiple myeloma. We present a case of a 63-year-old woman who was found to have anemia during her medical checkup. Her blood tests suggested multiple myeloma, but she had diffuse osteosclerotic changes mainly in the axial skeleton, such as osteoblastic bone metastasis. On the other hand, the bone scintigraphy and FDG-PET showed almost normal. Osteosclerosing myeloma is similar to osteoblastic bone metastases and POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome, but is characterized by a lack of response to nuclear medicine testing, reflecting very low activity. This case highlights the critical value of the image findings of osteosclerosis myeloma and promotes awareness of this highly unusual but unique form of the disease.
期刊介绍：
The content of this journal is exclusively case reports that feature diagnostic imaging. Categories in which case reports can be placed include the musculoskeletal system, spine, central nervous system, head and neck, cardiovascular, chest, gastrointestinal, genitourinary, multisystem, pediatric, emergency, women''s imaging, oncologic, normal variants, medical devices, foreign bodies, interventional radiology, nuclear medicine, molecular imaging, ultrasonography, imaging artifacts, forensic, anthropological, and medical-legal. Articles must be well-documented and include a review of the appropriate literature.
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