Efficient Route to N-Substituted β-Amido Ketone Scaffold Using Bismuth Nitrate-Catalyzed One-Pot MCR Protocol

Abstract

A new catalytic one-pot synthesis of N-substituted β-amido carbonyl compounds has been developed using bismuth nitrate as highly efficient, commercially available, recyclable, and reusable acid catalyst. The efficiency of the proposed protocol was demonstrated by 17 examples including various functionalized N-substituted β-amido carbonyl compounds. The reaction utilized easily available and cost-effective starting materials and proceeded at room temperature in a short period of time, followed by aqueous workup.