{"title":"Front Cover: A Promising Approach to Target Colorectal Cancer Using Hybrid Triarylmethanes (ChemMedChem 21/2024)","authors":"Ameni Hadj Mohamed, Christophe Ricco, Aline Pinon, Nathalie Lagarde, Elizabeth Goya-Jorge, Hadley Mouhsine, Moncef Msaddek, Bertrand Liagre, Maité Sylla-Iyarreta Veitía","doi":"10.1002/cmdc.202482101","DOIUrl":null,"url":null,"abstract":"<p>The Front Cover features a potential inhibitor targeting the protein kinase B (AKT), N-oxide hybrid triarylmethane type. The mechanism of action of its antiproliferative activity was validated through in silico studies and biological tests on colorectal cancer cells lines. More details can be found in article 10.1002/cmdc.202400151 by Bertrand Liagre, M. Sylla-Iyarreta Veitía, and co-workers. Cover design was generated using the high-performance molecular visualization software VTX (https://vtx.drugdesign.fr).\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"19 21","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.202482101","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemMedChem","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cmdc.202482101","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
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Abstract
The Front Cover features a potential inhibitor targeting the protein kinase B (AKT), N-oxide hybrid triarylmethane type. The mechanism of action of its antiproliferative activity was validated through in silico studies and biological tests on colorectal cancer cells lines. More details can be found in article 10.1002/cmdc.202400151 by Bertrand Liagre, M. Sylla-Iyarreta Veitía, and co-workers. Cover design was generated using the high-performance molecular visualization software VTX (https://vtx.drugdesign.fr).
期刊介绍：
Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs.
Contents
ChemMedChem publishes an attractive mixture of:
Full Papers and Communications
Reviews and Minireviews
Patent Reviews
Highlights and Concepts
Book and Multimedia Reviews.
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