The Latest Applications of Carbon-Nitride-Based Materials for Combination Treatment of Cancer

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Applied Materials & Interfaces Pub Date : 2024-11-12 DOI:10.1021/acsami.4c12350

Xu-Feng Ning, Ya-Qi Zhu, Hao Sun, Yuan Yang, Ming-Xuan Liu

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Abstract

Carbon-nitride-based (CN-based) materials have shown great potential in combination therapy in recent years. Due to their outstanding biocompatibility, ease of modification, and adjustable band-gap position, CN-based materials can be applied as photosensitizers in photodynamic therapy (PDT) and light-driven water-splitting catalysts in gas therapy. After doping with other elements, the photocatalytic performance of CN-based materials will be enhanced, and more interesting functions will be obtained. In addition, the large specific surface area also promotes CN-based materials as drug carriers combined with other therapeutic modalities to achieve combination therapy. This Review analyzes and summarizes the latest research on CN-based materials in combined therapies, such as PDT with photothermal therapy (PTT), PDT with sonodynamic therapy (SDT), PDT with drug therapy, PDT with gene therapy, gas therapy with PDT, and bioimaging-guided combined therapy. In particular, the applications of CN-based materials in gas and gene combination therapy are summarized for the first time. Finally, the current challenges faced by CN-based materials in combination therapy are further discussed.

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氮化碳基材料在癌症综合治疗中的最新应用

近年来，氮化碳（CN）基材料在联合治疗方面显示出巨大潜力。由于其出色的生物相容性、易修饰性和可调节的带隙位置，氮化萘基材料可用作光动力疗法（PDT）中的光敏剂和气体疗法中的光驱动分水催化剂。在掺杂其他元素后，CN 基材料的光催化性能将得到增强，并获得更多有趣的功能。此外，大比表面积也促进了 CN 基材料作为药物载体与其他治疗方式相结合，实现联合治疗。本综述分析并总结了有关 CN 基材料在联合疗法中的最新研究，例如光热效应疗法（PDT）与光热疗法（PTT）、光热效应疗法与声动力疗法（SDT）、光热效应疗法与药物疗法、光热效应疗法与基因疗法、光热效应疗法与气体疗法以及生物成像引导的联合疗法。特别是首次总结了氯化萘基材料在气体和基因联合疗法中的应用。最后，进一步讨论了目前 CN 基材料在联合疗法中面临的挑战。

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.