A systemic effect for liver senescence

IF 17.3 1区生物学 Q1 CELL BIOLOGY Nature Cell Biology Pub Date : 2024-11-13 DOI:10.1038/s41556-024-01520-w

Kuo Du, David Scott Umbaugh, Rajesh Kumar Dutta, Anna Mae Diehl

引用次数: 0

Abstract

A study shows that senescence induced in the liver can spread systemically to precipitate multi-organ dysfunction. The work identifies TGFβ signalling as a key mediator of this transmission, suggesting therapeutic avenues to prevent multi-organ failure in severe liver diseases.

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肝脏衰老的系统效应

一项研究表明，肝脏诱发的衰老可向全身扩散，导致多器官功能障碍。研究发现，TGFβ信号是这种传播的关键介质，这为预防严重肝病的多器官功能衰竭提供了治疗途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology

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