The effect of cortisone on female zebrafish (Dania rerio): Reducing reproductive capacity and offspring survival rate

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY Aquatic Toxicology Pub Date : 2024-10-28 DOI:10.1016/j.aquatox.2024.107132

MeiXin Ye , JinLin Yang , ZiPing Cai , JunHao Wu , Wenting Xiong , LiPing Hou

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Abstract

Cortisone is a naturally occurring corticosteroid hormone known for its wide range of anti-inflammatory and immunosuppressive effects, and it is commonly found in various aquatic environments. Previous reports have shown that cortisone can have significant negative impacts on fish; however, its specific effects on fish reproduction have not been thoroughly investigated. In this study, female adult zebrafish were exposed to 0.0 (control), 3.9, 40.2, and 377.9 ng/L of cortisone for 60 days, and multiple endpoints were evaluated. The results showed that as the concentration of cortisone increased, there was an increase in the percentage of perinuclear oocytes and a decrease in the proportion of late-stage oocytes, indicating a stagnation in oocyte development. Additionally, female zebrafish exposed to cortisone exhibited decreased attraction to males and reduced mating intimacy. Furthermore, exposure to cortisone resulted in changes in the development and behavior of zebrafish embryos. At cortisone concentrations of 3.9 and 40.2 ng/L, fewer eggs were laid and the survival rate of fertilized eggs decreased. These observed effects are associated with abnormal transcription levels of genes (Star, Cyp11a1, Cyp17, Cyp19a, Cyp11b, Hsd11β2, Hsd17β3) related to the HPG axis. These findings provided new insights into understanding potential environmental risks associated with corticosteroids.

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可的松对雌性斑马鱼（Dania rerio）的影响：降低生殖能力和后代存活率

可的松是一种天然的皮质类固醇激素，具有广泛的消炎和免疫抑制作用，常见于各种水生环境中。以往的报告显示，可的松会对鱼类产生严重的负面影响，但其对鱼类繁殖的具体影响尚未得到深入研究。本研究将雌性成年斑马鱼暴露于 0.0（对照组）、3.9、40.2 和 377.9 纳克/升的可的松浓度下 60 天，并对多个终点进行了评估。结果显示，随着可的松浓度的增加，围核卵母细胞的比例增加，晚期卵母细胞的比例减少，表明卵母细胞发育停滞。此外，暴露于可的松的雌性斑马鱼对雄性斑马鱼的吸引力下降，交配亲密性降低。此外，暴露于可的松还会导致斑马鱼胚胎的发育和行为发生变化。可的松浓度为 3.9 和 40.2 纳克/升时，斑马鱼产卵量减少，受精卵存活率降低。这些观察到的影响与 HPG 轴相关基因（Star、Cyp11a1、Cyp17、Cyp19a、Cyp11b、Hsd11β2、Hsd17β3）的转录水平异常有关。这些发现为了解与皮质类固醇相关的潜在环境风险提供了新的视角。

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来源期刊

Aquatic Toxicology 环境科学-毒理学

CiteScore

7.10

自引率

4.40%

发文量

250

审稿时长

56 days

期刊介绍： Aquatic Toxicology publishes significant contributions that increase the understanding of the impact of harmful substances (including natural and synthetic chemicals) on aquatic organisms and ecosystems. Aquatic Toxicology considers both laboratory and field studies with a focus on marine/ freshwater environments. We strive to attract high quality original scientific papers, critical reviews and expert opinion papers in the following areas: Effects of harmful substances on molecular, cellular, sub-organismal, organismal, population, community, and ecosystem level; Toxic Mechanisms; Genetic disturbances, transgenerational effects, behavioral and adaptive responses; Impacts of harmful substances on structure, function of and services provided by aquatic ecosystems; Mixture toxicity assessment; Statistical approaches to predict exposure to and hazards of contaminants The journal also considers manuscripts in other areas, such as the development of innovative concepts, approaches, and methodologies, which promote the wider application of toxicological datasets to the protection of aquatic environments and inform ecological risk assessments and decision making by relevant authorities.