Cognitive functions among school-going children and adolescents with type 1 diabetes mellitus: Matched case-control cross-sectional study.

IF 1.7 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Saudi Medical Journal Pub Date : 2024-11-01 DOI:10.15537/smj.2024.45.11.20240509
Sultan A Meo, Metib Alotaibi, Narmeen Shaikh, Reem AlKhalifah
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Abstract

Objectives: To investigate the cognitive performance of Saudi children and adolescents with type 1 diabetes mellitus (T1DM) compared to matched control groups.

Methods: A total of 64 participants (32 T1DM patients and 32 control), matched with age, gender, ethnicity, education, and body mass index were recruited. Cognitive functions were investigated using a highly reliable and valid "Cambridge neuropsychological test automated battery". The attention switching task (AST) and choice reaction time (CRT) test were carried out to evaluate the cognitive functions.

Results: The cognitive test parameters AST mean correct latency, AST mean correct latency (congruent), AST mean correct latency (incongruent), and CRT mean correct latency were significantly delayed in the T1DM group compared to their control group (p<0.0001). Moreover, the control group did significantly better on the cognitive test parameters AST and CRT than the T1DM children and adolescents with hemoglobin A1c (HbA1C) ≥8% group (p<0.01).

Conclusion: The findings demonstrate a delay in cognitive performance among children and adolescents with T1DM. Importantly, elevated HbA1C levels and duration of disease were associated with reduced cognitive functions. The present study findings highlight the importance of stringent glycemic management in children and adolescents with T1DM. The findings can support physicians and policymakers not only to prevent microvascular complications but also to mitigate potential cognitive deficits among children and adolescents with T1DM.

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1 型糖尿病学龄儿童和青少年的认知功能:匹配病例对照横断面研究。
目的:研究患有 1 型糖尿病(T1DM)的沙特儿童和青少年的认知能力:研究患有 1 型糖尿病(T1DM)的沙特儿童和青少年与匹配的对照组相比的认知能力:方法:共招募了 64 名参与者(32 名 T1DM 患者和 32 名对照组),年龄、性别、种族、教育程度和体重指数均匹配。认知功能采用高度可靠和有效的 "剑桥神经心理测试自动电池 "进行调查。对认知功能的评估包括注意力转换任务(AST)和选择反应时间(CRT)测试:结果:与对照组相比,T1DM 组的认知测试参数 AST 平均正确潜伏期、AST 平均正确潜伏期(一致)、AST 平均正确潜伏期(不一致)和 CRT 平均正确潜伏期明显延迟(ppConclusion):研究结果表明,患有 T1DM 的儿童和青少年在认知能力方面存在延迟。重要的是,HbA1C 水平的升高和病程的延长与认知功能的降低有关。本研究结果强调了对患有 T1DM 的儿童和青少年进行严格血糖管理的重要性。研究结果不仅能帮助医生和决策者预防微血管并发症,还能减轻 T1DM 儿童和青少年潜在的认知障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Saudi Medical Journal
Saudi Medical Journal 医学-医学:内科
CiteScore
2.30
自引率
6.20%
发文量
203
审稿时长
12 months
期刊介绍: The Saudi Medical Journal is a monthly peer-reviewed medical journal. It is an open access journal, with content released under a Creative Commons attribution-noncommercial license. The journal publishes original research articles, review articles, Systematic Reviews, Case Reports, Brief Communication, Brief Report, Clinical Note, Clinical Image, Editorials, Book Reviews, Correspondence, and Student Corner.
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